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FLASH GENE
Symbol LZTFL1 contributors: mct - updated : 06-03-2013
HGNC name leucine zipper transcription factor-like 1
HGNC id 6741
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
leucine zipper and coiled-coil domain
HOMOLOGY
interspecies ortholog to murine Lztfl1
homolog to rattus Rn.25212
homolog to xenopus Xl.15357
homolog to zebrafish Dr.12106
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • may inhibit tumorigenesis by stabilizing CDH1-mediated adherens junction formation and promoting epithelial cell differentiation
  • BBS proteins and LZTFL1 regulate ciliary trafficking of hedgehog signal transducer, Smoothened
  • important regulator of BBSome ciliary trafficking and hedgehog signaling
  • important negative regulator of BBSome ciliary trafficking and SHH signalling
  • play a central role in the regulation of the actin cytoskeleton and control the cilia length through alteration of RHOA levels
  • it is likely that LZTFL1 functions downstream of IFT27 to couple the BBSome to the IFT particle for coordinated removal of patched-1 and Smoothened from cilia during hedgehog signaling
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with a BBS protein complex known as the BBSome and regulates ciliary trafficking of this complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BBS17
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker its expression may serve as an independent prognostic marker for survival outcome of gastric cancer patients
    Therapy target
    ANIMAL & CELL MODELS