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FLASH GENE
Symbol LZTFL1 contributors: mct - updated : 06-03-2013
HGNC name leucine zipper transcription factor-like 1
HGNC id 6741
Corresponding disease
BBS17 Bardet-Biedl syndrome 17
Location 3p21.31      Physical location : 45.865.445 - 45.883.621
Synonym symbol(s) BBS17
DNA
TYPE like-sequence
STRUCTURE 18.17 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 polyA site 3398 34.6 299 predominantly pancreas, thymus, testis, fetal kidney Kiss
- polyA site 4356 - 282 testis, heart, skeletal muscle, pancreas, fetal kidney Kiss
- - 4127 - 256 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus   highly
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbrain   moderately
Respiratorylung   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier lining  highly Homo sapiensAdult
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
leucine zipper and coiled-coil domain
HOMOLOGY
interspecies ortholog to murine Lztfl1
homolog to rattus Rn.25212
homolog to xenopus Xl.15357
homolog to zebrafish Dr.12106
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • may inhibit tumorigenesis by stabilizing CDH1-mediated adherens junction formation and promoting epithelial cell differentiation
  • BBS proteins and LZTFL1 regulate ciliary trafficking of hedgehog signal transducer, Smoothened
  • important regulator of BBSome ciliary trafficking and hedgehog signaling
  • important negative regulator of BBSome ciliary trafficking and SHH signalling
  • play a central role in the regulation of the actin cytoskeleton and control the cilia length through alteration of RHOA levels
  • it is likely that LZTFL1 functions downstream of IFT27 to couple the BBSome to the IFT particle for coordinated removal of patched-1 and Smoothened from cilia during hedgehog signaling
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with a BBS protein complex known as the BBSome and regulates ciliary trafficking of this complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BBS17
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker its expression may serve as an independent prognostic marker for survival outcome of gastric cancer patients
    Therapy target
    ANIMAL & CELL MODELS