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FLASH GENE

Symbol

LZTFL1

contributors: mct - updated : 06-03-2013

HGNC name	leucine zipper transcription factor-like 1
HGNC id	6741

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020347 10 polyA site 3398 NP_065080 34.6 299 predominantly pancreas, thymus, testis, fetal kidney Kiss NM_001276378 - polyA site 4356 NP_001263307 - 282 testis, heart, skeletal muscle, pancreas, fetal kidney Kiss NM_001276379 - - 4127 NP_001263308 - 256 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus       highly Digestive liver       moderately Endocrine pancreas       moderately Nervous brain       moderately Respiratory lung       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining     highly Homo sapiens Adult Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

leucine zipper and coiled-coil domain

HOMOLOGY

interspecies	ortholog to murine Lztfl1
	homolog to rattus Rn.25212
	homolog to xenopus Xl.15357
	homolog to zebrafish Dr.12106

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	may inhibit tumorigenesis by stabilizing CDH1-mediated adherens junction formation and promoting epithelial cell differentiation
	BBS proteins and LZTFL1 regulate ciliary trafficking of hedgehog signal transducer, Smoothened
	important regulator of BBSome ciliary trafficking and hedgehog signaling
	important negative regulator of BBSome ciliary trafficking and SHH signalling
	play a central role in the regulation of the actin cytoskeleton and control the cilia length through alteration of RHOA levels
	it is likely that LZTFL1 functions downstream of IFT27 to couple the BBSome to the IFT particle for coordinated removal of patched-1 and Smoothened from cilia during hedgehog signaling

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

interacts with a BBS protein complex known as the BBSome and regulates ciliary trafficking of this complex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

BBS17

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	its expression may serve as an independent prognostic marker for survival outcome of gastric cancer patients
Therapy target

ANIMAL & CELL MODELS