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FLASH GENE
Symbol KLC3 contributors: mct - updated : 24-03-2022
HGNC name kinesin light chain 3
HGNC id 20717
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal domain with heptad repeats typical of the rod domain of cytoskeletal proteins
  • a central and C terminal consisting of 6 TPR repeats of approximatively 21 aminoacids
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to purple sea urchin Spklc
    homolog to chimpanzee KLC3 (97.0pc)
    Homologene
    FAMILY
  • kinesin light chain family
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule
    text elongating spermatid tail midpiece, localized in outer dense fibers and associating with mitochondria
    basic FUNCTION
  • playing a role in organelle transport
  • functioning in coupling cargo to the heavy chain or in the modulation of its ATPase activity
  • involved in binding cargo and regulating kinesin activity
  • could play a microtubule-independent role during formation of sperm tails
  • only known kinesin light chain expressed in post-meiotic male germ cells
  • KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • oligomeric complex composed of two heavy chains and two light chains
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to microtubule
  • binding to ODF1
  • mitochondrial outer membrane porin protein VDAC2 is a KLC3 binding partner
  • LRGUK binding to KLC3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression of KLC3 was significantly higher in asthenozoospermic compared to non-asthenozoospermic individuals
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS