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FLASH GENE

Symbol

KLC3

contributors: mct - updated : 24-03-2022

HGNC name	kinesin light chain 3
HGNC id	20717

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland         Reproductive female system ovary         male system testis       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal domain with heptad repeats typical of the rod domain of cytoskeletal proteins
	a central and C terminal consisting of 6 TPR repeats of approximatively 21 aminoacids

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to purple sea urchin Spklc
	homolog to chimpanzee KLC3 (97.0pc)

Homologene

FAMILY

kinesin light chain family

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytoskeleton,microtubule
text	elongating spermatid tail midpiece, localized in outer dense fibers and associating with mitochondria

basic FUNCTION	playing a role in organelle transport
	functioning in coupling cargo to the heavy chain or in the modulation of its ATPase activity
	involved in binding cargo and regulating kinesin activity
	could play a microtubule-independent role during formation of sperm tails
	only known kinesin light chain expressed in post-meiotic male germ cells
	KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

oligomeric complex composed of two heavy chains and two light chains

INTERACTION

DNA

RNA

small molecule

protein	binding to microtubule
	binding to ODF1
	mitochondrial outer membrane porin protein VDAC2 is a KLC3 binding partner
	LRGUK binding to KLC3

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   expression of KLC3 was significantly higher in asthenozoospermic compared to non-asthenozoospermic individuals

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS