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FLASH GENE

Symbol

CAP1

contributors: mct - updated : 03-05-2017

HGNC name	CAP, adenylate cyclase-associated protein 1 (yeast)
HGNC id	20040

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	32.58 kb     13 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006367 13 - 2798 NP_006358 - 475 - 2002 11950878 NM_001105530 13 - 2780 NP_001099000 - 475 - 2002 11950878 NM_001330502 - - 2770 NP_001317431 - 474 - 2002 11950878 NM_001350475 - - 2848 NP_001337404 - 475 - 2002 11950878 NM_001350476 - - 2783 NP_001337405 - 475 - 2002 11950878 NM_001350477 - - 2801 NP_001337406 - 475 - 2002 11950878 NM_001350478 - - 2866 NP_001337407 - 475 - 2002 11950878 NM_001350479 - - 2985 NP_001337408 - 475 - 2002 11950878 NM_001350480 - - 2982 NP_001337409 - 475 - 2002 11950878 NM_001350482 - - 2798 NP_001337411 - 474 - 2002 11950878 NM_001350481 - - 2875 NP_001337410 - 475 - 2002 11950878 NM_001350483 - - 2780 NP_001337412 - 474 - 2002 11950878 NM_001350484 - - 2860 NP_001337413 - 474 - 2002 11950878 NM_001350485 - - 2777 NP_001337414 - 474 - 2002 11950878

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine small intestine     highly Lymphoid/Immune tonsils       highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to yeast S.cerevisiae Srv2p
	ortholog to murine Cap1

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	involved in establishment and/or maintenance of cell polarity
	playing a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin
	CAP1 provides likely a direct link from the actin cytoskeleton to the mitochondria by functioning as an actin shuttle
	involvement of CAP1 in the aggressive behavior of pancreatic cancer cells
	novel cellular function for CAP1 in regulating cell adhesion
	involved in the regulation of actin filaments, and recently reported to play a role in cell motility and the pathology of pancreatic cancer
	is the bona fide receptor for resistin leading to inflammation
	play a role in cell motility and in the development of certain types of cancer
	exerts cell type-dependent functions in the invasiveness of breast cancer cells
	functions for CAP1 in cancer cell proliferation and anchorage-independent growth, again in a cell context-dependent manner

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	cell polarity

PATHWAY

metabolism

signaling

signal transduction

cAMP pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to adenyl cyclase , CAP2, actin
	identified as a novel and most efficient substrate of gelatinase B/MMP9
	actin- and cofilin-interacting protein CAP1 has a role in apoptosis
	CAP1 is a functional receptor for RETN that directly binds to CAP1 in monocytes and upregulates cyclic AMP (cAMP) concentration, protein kinase A (PRKA) activity, and NFKB1-related transcription of inflammatory cytokine

cell & other

REGULATION

Other

pPhosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in human glioma tumoral     --over   is involved in the pathogenesis of epithelial ovarian cancer (EOC) tumoral     --over   might contribute heavily to the metastasis of Hepatocellular carcinoma (HCC) tumoral     --over   1 in lung cancer cells, particularly at the metastatic stage, may have significant clinical implications as a diagnostic/prognostic factor for lung cancer tumoral     --over   in pancreatic cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	CAP1 could be an independent prognostic factor for patients survival in Hepatocellular carcinoma (HCC)
Therapy target
	System Type Disorder Pubmed cancer brain   downregulation of CAP1 in tumors may serve as a treatment for glioma patients cancer reproductive ovary downregulation of CAP1 in tumor cells may be a therapeutic target for the treatment of patients with EOC

ANIMAL & CELL MODELS