Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TOP3A

contributors: mct - updated : 11-09-2018

HGNC name	topoisomerase (DNA) III alpha
HGNC id	11992

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BLMLS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fused to KMT12A in an adult patient with acute myeloid leukaemia

Susceptibility

Variant & Polymorphism

Candidate gene	TOP3A could be a candidate gene involved in human primary immunodeficiency syndrome
Marker
Therapy target	)
	System Type Disorder Pubmed tumor     potential role in dissociating telomeric structures in telomerase-deficient cells, providing therapeutic implications in human tumors

ANIMAL & CELL MODELS