| 1 | BLM, RMI1, RMI2, TOP3A
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| Mutations in TOP3A Cause a Bloom Syndrome-like Disorder.
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| Martin CA, Sarlós K, Logan CV, Thakur RS, Parry DA, Bizard AH, Leitch A, Cleal L, Ali NS, Al-Owain MA, Allen W, Altmüller J, Aza-Carmona M, Barakat BAY, Barraza-García J, Begtrup A, Bogliolo M, Cho MT, Cruz-Rojo J, Dhahrabi HAM, Elcioglu NH; GOSgene, Gorman GS, Jobling R, Kesterton I, Kishita Y, Kohda M, Le Quesne Stabej P, Malallah AJ, Nürnberg P, Ohtake A, Okazaki Y, Pujol R, Ramirez MJ, Revah-Politi A, Shimura M, Stevens P, Taylor RW, Turner L, Williams H, Wilson C, Yigit G, Zahavich L, Alkuraya FS, Surralles J, Iglesais A, Murayama K, Wollnik B, Dattani M, Heath KE, Hickson ID, Jackson AP.
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| Am J Hum Genet 103(2):221-231. doi: 10.1016/j.ajhg.2018.07.001. Epub 2018 Jul 26. Erratum in: Am J Hum Genet. 2018 Sep 6;103(3):456.
2018
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| 2 | PEOB5, TOP3A
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| Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.
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| Nicholls TJ, Nadalutti CA, Motori E, Sommerville EW, Gorman GS, Basu S, Hoberg E, Turnbull DM, Chinnery PF, Larsson NG, Larsson E, Falkenberg M, Taylor RW, Griffith JD, Gustafsson CM.
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| Mol Cell 69(1):9-23.e6. doi: 10.1016/j.molcel.2017.11.033. Epub 2017 Dec 28.
2018
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| 3 | BLM, RMI1, RMI2, TOP3A
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| Knockdown of RMI1 impairs DNA repair under DNA replication stress.
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| Xu C, Fang L, Kong Y, Xiao C, Yang M, Du LQ, Liu Q.
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| Biochem Biophys Res Commun 494(1-2):158-164. doi: 10.1016/j.bbrc.2017.10.062. Epub 2017 Oct 14.
2017
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| 4 | TOP3A
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| Drosophila mitochondrial topoisomerase III alpha affects the aging process via maintenance of mitochondrial function and genome integrity.
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| Tsai HZ, Lin RK, Hsieh TS.
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| J Biomed Sci 23:38. doi: 10.1186/s12929-016-0255-2.
2016
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| 5 | RMI1, RMI2, TOP3A
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| Accumulation and Phosphorylation of RecQ-Mediated Genome Instability Protein 1 (RMI1) at Serine 284 and Serine 292 during Mitosis.
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| Xu C, Wang Y, Wang L, Wang Q, Du LQ, Fan S, Liu Q, Li L.
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| Int J Mol Sci 16(11):26395-405. doi: 10.3390/ijms161125965.
2015
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| 6 | BLM, RMI1, RMI2, TOP3A
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| Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.
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| Daley JM, Chiba T, Xue X, Niu H, Sung P.
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| Nucleic Acids Res 42(17):11083-91. doi: 10.1093/nar/gku803. Epub 2014 Sep 8.
2014
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| 7 | RMI1, TOP3A
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| Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1.
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| Bocquet N, Bizard AH, Abdulrahman W, Larsen NB, Faty M, Cavadini S, Bunker RD, Kowalczykowski SC, Cejka P, Hickson ID, Thomä NH.
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| Nat Struct Mol Biol 21(3):261-8. doi: 10.1038/nsmb.2775. Epub 2014 Feb 9.
2014
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| 8 | CDKN1A, TOP3A, TP53
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| DNA topoisomerase III alpha regulates p53-mediated tumor suppression.
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| Hsieh MY, Fan JR, Chang HW, Chen HC, Shen TL, Teng SC, Yeh YH, Li TK.
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| Clin Cancer Res 20(6):1489-501. doi: 10.1158/1078-0432.CCR-13-1997. Epub 2014 Feb 13.
2014
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| 9 | BLM, RMI1, RMI2, TOP3A
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| Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis.
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| Pradhan A, Singh TR, Ali AM, Wahengbam K, Meetei AR.
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| J Biol Chem 288(47):33500-8. doi: 10.1074/jbc.M113.470823. Epub 2013 Oct 9.
2013
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| 10 | BLM, RMI1, RMI2, TOP3A
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| RMI1 promotes DNA replication fork progression and recovery from replication fork stress.
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| Yang J, O'Donnell L, Durocher D, Brown GW.
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| Mol Cell Biol 32(15):3054-64. doi: 10.1128/MCB.00255-12. Epub 2012 May 29.
2012
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| 11 | TDP2, TOP2A, TOP3A
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| Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.
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| Gao R, Huang SY, Marchand C, Pommier Y.
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| J Biol Chem 287(36):30842-52. doi: 10.1074/jbc.M112.393983. Epub 2012 Jul 20.
2012
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| 12 | TOP1MT, TOP2B, TOP3A
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| Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.
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| Douarre C, Sourbier C, Dalla Rosa I, Brata Das B, Redon CE, Zhang H, Neckers L, Pommier Y.
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| PLoS One 7(7):e41094. doi: 10.1371/journal.pone.0041094. Epub 2012 Jul 20.
2012
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| 13 | BLM, RMI1, TOP3A
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| Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.
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| Yang J, Bachrati CZ, Ou J, Hickson ID, Brown GW.
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| J Biol Chem 285(28):21426-36. doi: 10.1074/jbc.M110.123216. Epub 2010 May 5. 2010
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| 14 | BLM, RMI1, RMI2, TOP3A
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| Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha.
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| Mönnich M, Hess I, Wiest W, Bachrati C, Hickson ID, Schorpp M, Boehm T.
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| Eur J Immunol 40(9):2379-84. doi: 10.1002/eji.201040634.
2010
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| 15 | BLM, RMI1, TOP3A
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| Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.
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| Broberg K, Huynh E, Schläwicke Engström K, Björk J, Albin M, Ingvar C, Olsson H, Höglund M.
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| BMC Cancer 9:140. doi: 10.1186/1471-2407-9-140.
2009
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| 16 | BLM, RMI1, RMI2, TOP3A
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| RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
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| Xu D, Guo R, Sobeck A, Bachrati CZ, Yang J, Enomoto T, Brown GW, Hoatlin ME, Hickson ID, Wang W.
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| Genes Dev 22(20):2843-55.
2008
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| 17 | BLM, RMI1, RMI2, TOP3A
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| BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
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| Singh TR, Ali AM, Busygina V, Raynard S, Fan Q, Du CH, Andreassen PR, Sung P, Meetei AR.
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| Genes Dev 22(20):2856-68. 2008
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| 18 | TOP3A
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| Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.
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| Temime-Smaali N, Guittat L, Wenner T, Bayart E, Douarre C, Gomez D, Giraud-Panis MJ, Londono-Vallejo A, Gilson E, Amor-Guéret M, Riou JF.
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| EMBO J 27(10):1513-24. Epub 2008 Apr 17.
2008
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| 19 | BLM, RMI1, TOP3A
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| Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.
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| Bussen W, Raynard S, Busygina V, Singh AK, Sung P.
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| J Biol Chem 282(43):31484-92. Epub 2007 Aug 28.
2007
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| 20 | RMI1, TOP3A, BLM
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| A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.
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| Raynard S, Bussen W, Sung P.
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| J Biol Chem 281(20):13861-4. Epub 2006 Apr 4. 2006
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| 21 | BLM, TOP3A
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| Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.
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| Seki M, Nakagawa T, Seki T, Kato G, Tada S, Takahashi Y, Yoshimura A, Kobayashi T, Aoki A, Otsuki M, Habermann FA, Tanabe H, Ishii Y, Enomoto T.
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| Mol Cell Biol 26(16):6299-307. 2006
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| 22 | TOP3A
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| Involvement of topoisomerase III in telomere-telomere recombination.
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| Tsai HJ, Huang WH, Li TK, Tsai YL, Wu KJ, Tseng SF, Teng SC.
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| J Biol Chem 281(19):13717-23. Epub 2006 Mar 16.
2006
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| 23 | RMI1, TOP3A, BLM
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| BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.
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| Yin J, Sobeck A, Xu C, Meetei AR, Hoatlin M, Li L, Wang W.
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| EMBO J 24(7):1465-76. Epub 2005 Mar 17. 2005
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| 24 | BLM, TOP3A
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| The Bloom's syndrome gene product interacts with topoisomerase III.
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| Wu L, Davies SL, North PS, Goulaouic H, Riou JF, Turley H, Gatter KC, Hickson ID.
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| J Biol Chem 275(13):9636-44. 2000
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| 25 | TOP3A, SMCR
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| Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region : analysis of cell-cycle distribution and radiation sensitivity.
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| Elsea SH, Fritz E, Schoener-Scott R, Meyn MS, Patel PI.
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| Am J Med Genet 75(1):104-8. 1998
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| 26 | TOP3A
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| Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene.
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| Kim JC, et al.
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| J Biol Chem 273 : 26130-26137. 1998
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| 27 | TOP3A
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| Human TOP3 : a single-copy gene encoding DNA topoisomerase III.
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| Hanai R, et al.
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| Proc Natl Acad Sci U S A 93 : 3653-3657. 1996
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