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FLASH GENE

Symbol

ASCL2

contributors: mct - updated : 21-09-2011

HGNC name	achaete-scute complex-like 2 (Drosophila)
HGNC id	739

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       intestine small intestine         stomach         Reproductive female system placenta     highly Homo sapiens

cell lineage	extravillus trophoblast
cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a basic helix-loop-helix (BHLH) domain

HOMOLOGY

interspecies

homolog to Drosophila achaete-scute 2

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system
	transcription factor essential for the maintenance of proliferating trophoblasts during placental development
	controls intestinal stem cell fate

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

dimerization with other BHLH proteins is required for efficient DNA binding

INTERACTION

DNA

RNA

small molecule

protein	activates transcription by binding to the E box (5'-CANNTG-3')
	inhibiting PCSK6 in placenta

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal adenocarcinomas constitutional       loss of function partial loss of function affects all three layers of the mature placenta and causes intrauterine growth restriction

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS