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FLASH GENE
Symbol ASCL2 contributors: mct - updated : 21-09-2011
HGNC name achaete-scute complex-like 2 (Drosophila)
HGNC id 739
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1864 - 193 - 1997 9175731
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
 stomach    
Reproductivefemale systemplacenta  highly Homo sapiens
cell lineage extravillus trophoblast
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic helix-loop-helix (BHLH) domain
  • HOMOLOGY
    interspecies homolog to Drosophila achaete-scute 2
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system
  • transcription factor essential for the maintenance of proliferating trophoblasts during placental development
  • controls intestinal stem cell fate
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dimerization with other BHLH proteins is required for efficient DNA binding
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activates transcription by binding to the E box (5'-CANNTG-3')
  • inhibiting PCSK6 in placenta
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal adenocarcinomas
    constitutional       loss of function
    partial loss of function affects all three layers of the mature placenta and causes intrauterine growth restriction
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS