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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ADM

contributors: mct - updated : 12-06-2016

HGNC name	adrenomedullin
HGNC id	259

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed in multiple myeloma and promotes angiogenesis constitutional     --over   significant increase of ADM, and TNF in the idiopathic IUGR tumoral     --over   in patients with pancreatic cancer and causes insulin resistance in beta cells constitutional     --over   in eyes with ocular pathologies such as diabetic retinopathy, glaucoma, retinitis pigmentosa, and uveitis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	proADM appears to have the advantage of predicting localized bacterial infection and differentiating sepsis from systemic inflammatory response syndrome, in febrile patients with hematologic malignancies
	dysregulated levels of ADM may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
Therapy target
	System Type Disorder Pubmed immunology inflammatory   has potential as a new therapeutic agent for the treatment of refractory ulcerative colitis immunology infectious   ADM/CFH is a novel therapy target for safe and effective therapy of patients with hemorrhagic shock, sepsis, and ischemic injury cancer angiogenesis   new potential therapy in cancer, complementary to other existing treatments

ANIMAL & CELL MODELS