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FLASH GENE
Symbol ADM contributors: mct - updated : 12-06-2016
HGNC name adrenomedullin
HGNC id 259
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
aberrantly expressed in multiple myeloma and promotes angiogenesis
constitutional     --over  
significant increase of ADM, and TNF in the idiopathic IUGR
tumoral     --over  
in patients with pancreatic cancer and causes insulin resistance in beta cells
constitutional     --over  
in eyes with ocular pathologies such as diabetic retinopathy, glaucoma, retinitis pigmentosa, and uveitis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • proADM appears to have the advantage of predicting localized bacterial infection and differentiating sepsis from systemic inflammatory response syndrome, in febrile patients with hematologic malignancies
  • dysregulated levels of ADM may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    has potential as a new therapeutic agent for the treatment of refractory ulcerative colitis
    immunologyinfectious 
    ADM/CFH is a novel therapy target for safe and effective therapy of patients with hemorrhagic shock, sepsis, and ischemic injury
    cancerangiogenesis 
    new potential therapy in cancer, complementary to other existing treatments
    ANIMAL & CELL MODELS