motifs/domains
| N-terminus containing only the two EF-hands and sterile alpha motif (SAM) domains, designated the EF-SAM domain  , sits inside the ER, where it senses luminal Ca2+ concentration |
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predicted signal peptide and transmembrane helix |
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107-AA CRAC activation domain (CAD) binding directly to the N and C termini of ORAI1 to open the CRAC channel |
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a STIM1 ORAI activating region (SOAR) region (AA fragment 344-442), acting in combination with STIM1 (AA 450-485) to regulate the strength of interaction with ORAI1 , and formation of a SOAR dimer is necessary to activate the ORAI1 channel |
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coiled-coil domain (CCB9)in the C terminus crucial for its aggregation, sufficient for binding to and activation of ORAI1 CRAC channels independent of store depletion |
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C terminus multimerizes two ORAI1 dimers to form the active channel ; cytosolic C terminus is sufficient to activate ORAI1 currents independent of store depletion , and C-terminal 200 AAs are important to maintain STIM1 in an inactive state when Ca2+ stores are full, through predicted intramolecular shielding of the active STIM1 domains (SOAR/CAD and STIM1 homomerization domain) , it is cytoplasmic |
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coiled-coil domains are essential for its ER-retention and its stability |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| text
| type 1 membrane protein |
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translocated across the membrane of the endoplasmic reticulum such that the SAM domain resides within the endoplasmic reticulum (ER) lumen |
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SURF4 associated with STIM1 in the endoplasmic reticulum |
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ASPH is a structural component of the ER-PM junctions where ORAI1 and STIM1 cluster and interact in T cells |
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translocating upon Ca2+ store depletion to the plasma membrane to activate calcium release-activated calcium channels |
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colocalized with T cell receptor molecules at the interface between T cells and dendritic cells |
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expressed in the lysosome-related organelles and dense granules in human platelets ) |
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primarily residing in the ER |
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STIM1 and ORAI1 are both localized at the skeletal-muscle triad, a specialized junction between the ER and the plasma membrane |
| basic FUNCTION
| implicated in tumor growth control and stromal-haematopoietic cell interactions |
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possible adhesion molecule with a role in early hematopoiesis by mediating attachment to stromal cells |
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playing a role in the negative regulation of progression through cell cycle |
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playing a role in the positive regulation of cell proliferation |
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being an essential component of CRAC (calcium-release-activated calcium) channel activation |
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activates the plasma membrane CRAC channels by binding to the N and C termini of ORAI1 |
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involved in vascular smooth muscle cells proliferation |
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being a key signal for SOC channel activation |
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recruited to the immunological synapse between primary T cells and autologous dendritic cells |
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critically involved in initiating of production of calcium influx factor (CIF), a diffusible messenger that can deliver the signal from the stores to plasma membrane |
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playing a role as a trigger for calcium influx factor production |
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responds to depletion of ER Ca2+ stores by rearranging from tubular structures throughout the ER into punctate structures near the plasma membrane, where it activates ORAI store-operated Ca2+ entry (SOCE) channels |
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may be communicating the intracellular Ca(2+) stores with the plasma membrane to mediate store-operated Ca(2+) entry |
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playing a role in the activation of store-operated Ca(2+) entry probably acting as a Ca(2+) sensor |
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essential function in mast cell activation and anaphylactic responses |
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transmembrane endoplasmic reticulum Ca2+ sensors, coupling directly to activate plasma membrane ORAI1 Ca2+ entry channels |
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gates the store-operated calcium channel ORAI1 |
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both STIM1 and STIM2 have a capacity to bind to a chaperone, calnexin as well as two protein-transporters, exportin1 and transportin1 |
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maintained in an inactive state in interphase with full Ca2+ stores through intramolecular shielding of the active domains (SOAR/CAD and SHD) by the C-terminal end of the molecule (positions 486–669) |
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STIM1 clustering inhibition during meiosis is independent of the C-terminal 200 AAs |
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potential functional role for STIM1 and STIM2 located in the acidic Ca2+ stores |
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expression of STIM1 and STIM2 in acidic organelles that function as agonist-sensitive Ca2+ stores |
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new actin-binding splice variant involved in fast repetitive Ca2+ release |
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endoplasmic reticulum (ER) membrane Ca(2+) sensor responsible for activation of store-operated Ca(2+) influx |
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calcium sensor in the endoplasmic reticulum, STIM1, activates ORAI1, a CRAC channel in the plasma membrane (PMId: 22451904) |
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essential for normal fertilization as it is involved in the maintenance of the long-lasting repetitive Ca(2+) signal ( |
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STIM1 acts as an endoplasmic reticulum (ER) Ca2+ sensor that detects store depletion |
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modulatory function of SURF4 for STIM1-mediated SOCE |
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essential for correct growth cone navigation, playing multiple roles in growth cone motility, including the activation of SOCE |
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potential role for STIM1, STIM2 proteins and T-cell function in the pathogenesis of Sjögren syndrome |
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could be an important molecule responsible for airway remodeling |
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is the endoplasmic reticulum (ER) Ca(2+) sensor to control ER Ca(2+) levels |
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store-operated Ca(2+) entry and STIM1 are involved in the regulation of mitochondrial shape and bioenergetics and play a role in oxidative stress |
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positive feedback control between STIM1/SOCE and NFATC3 is required for efficient induction and progression of myoblast differentiation |
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main Ca2+ sensor in the endoplasmic reticulum |
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oligomerizes and thereby triggers extracellular Ca2+ entry |
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importance of STIM1 in blood platelets, T cell activation, and normal skeletal-muscle structure and function |
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acts as an endoplasmic reticulum Ca(2+) sensor that communicates the filling state of the intracellular stores to the store-operated channels ( |
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functional role of plasma membrane-resident STIM1 in the regulation of store-operated divalent cation entry, which at least involves the EF-hand motif and the C-terminal polybasic lysine-rich domain ( |
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key component of intracellular Ca(2+) signaling, involved in the regulation not only of basolateral but also of apical Ca(2+) influx |
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central role of STIM1 and ORAI1 in SCDI (Slow Ca(2+)-dependent inactivation) |
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STIM1 and STIM2 Ca2+ sensors oligomerize upon Ca2+ depletion in the ER lumen, contact phosphoinositides at the PM via their cytosolic lysine (K)-rich domains, and activate Ca2+ channels |
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STIM1 and STIM2 are endoplasmic reticulum (ER) Ca(2+) sensor proteins able to translocate within the ER membrane to physically couple with and gate plasma membrane ORAI1 Ca(2+) channels |
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in the mammalian nervous system STIM1 is a key regulator of intracellular Ca(2+) signaling, metabotropic glutamate receptor-dependent synaptic transmission, and motor coordination |
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STIM1, STIM2, and ORAI1 regulate store-operated calcium entry and purinergic activation of microglia |
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STIM2 enhances agonist-mediated activation of SOCE by promoting STIM1 clustering in ER-PM junctions at low stimulus intensities |
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ability of STIM proteins to induce cortical ER formation is dispensable for SOCE and requires the lysine-rich tail of STIM1 involved in binding to phosphoinositides |
