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FLASH GENE
Symbol MUC2 contributors: mct/npt - updated : 11-06-2008
HGNC name mucin 2, oligomeric mucus/gel-forming
HGNC id 7512
Location 11p15.5      Physical location : 1.074.874 - 1.104.417
Synonym name
  • mucin-like protein
  • mucin 2, intestinal/tracheal
  • intestinal mucin-2
    • Synonym symbol(s) MLP, SMUC
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE component of a cluster, opposite orientation
    text clustered to chromosome 11p15.5 with three other secreted gel-forming mucins, MUC6, MUC5B, and MUC5AC
    STRUCTURE 29.00 kb     49 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    text structure binding sites for sp-family transcription factor
    MAPPING cloned Y linked Y status confirmed
    Map see INS , MUC6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    49 splicing 15728 540 5179 - Ahn, Semino-Mora (2008)
    - splicing 326 - 109 - Sternberg
    - splicing 1442 - 147 - Sternberg
    lacking the MUC2 TR2 repeat
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     stomach    
    respiratorylungbronchi   
    Respiratoryrespiratory tracttrachea   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lininguroepithelium  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed during embryonic development of the intestine, in a specific spatio-temporal pattern of expression
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an extended array of tandem repeats flanked by cysteine-rich subdomains
  • cystine Knot domain (at C terminus)
  • two VWF type D domain
    • conjugated GlycoP
    mono polymer polymer
    HOMOLOGY
    interspecies homolog to murine Muc2
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in epithelial cell differentiation
  • coating the epithelia of the intestines, airways and other mucus membrane containing organs, against particles and infections agents
  • contribute in mucus formation by forming a tridimensional network via oligomerization domains to protect underlying epithelia against diverse injuries
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • glycoprotein constituent of membrane
  • main protein component of intestinal mucus
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by FOXA1, FOXA2
    regulated by histone H3 modification and DNA methylation in pancreatic cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in epithelial ovarian cancer and in bladder cancer
    tumoral     --other  
    aberrant MUC2 expression in intestinal cancers and other intestinal disorders
    tumoral     --other  
    expression pattern of secreted mucins including MUC2 and MUC6 is altered apparently in gastric carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS