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| mice overexpress the 4R human tau isoform develop axonal degeneration in brain and spinal cord | |
mice expressing mutant (P301L) tau protein exhibit neurofibrillary tangles amyotrophy and progressive motor disturbance |
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double mutant (tau/APP (beta-amyloid precursor protein)) mice develop Abeta deposits and exhibit neurofibrillary tangle pathology enhanced in the limbic system and olfactory cortex |
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mice expressing a repressible human tau variant developed progressive age-related neurofibrillary tangles, neuronal loss, and behavioral impairments |