| 1 | APOE, MAPT, MOBP
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| Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia
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| Manzoni C, Kia DA, Ferrari R, Leonenko G, Costa B, Saba V, Jabbari E, Tan MM, Albani D, Alvarez V, Alvarez I, Andreassen OA, Angiolillo A, Arighi A, Baker M, Benussi L, Bessi V, Binetti G, Blackburn DJ, Boada M, Boeve BF, Borrego-Ecija S, Borroni B, Bråthen G, Brooks WS, Bruni AC, Caroppo P, Bandres-Ciga S, Clarimon J, Colao R, Cruchaga C, Danek A, de Boer SC, de Rojas I, di Costanzo A, Dickson DW, Diehl-Schmid J, Dobson-Stone C, Dols-Icardo O, Donizetti A, Dopper E, Durante E, Ferrari C, Forloni G, Frangipane F, Fratiglioni L, Kramberger MG, Galimberti D, Gallucci M, García-González P, Ghidoni R, Giaccone G, Graff C, Graff-Radford NR, Grafman J, Halliday GM, Hernandez DG, Hjermind LE, Hodges JR, Holloway G, Huey ED, Illán-Gala I, Josephs KA, Knopman DS, Kristiansen M, Kwok JB, Leber I, Leonard HL, Libri I, Lleo A, Mackenzie IR, Madhan GK, Maletta R, Marquié M, Maver A, Menendez-Gonzalez M, Milan G, Miller BL, Morris CM, Morris HR, Nacmias B, Newton J, Nielsen JE, Nilsson C, Novelli V, Padovani A, Pal S, Pasquier F, Pastor P, Perneczky R, Peterlin B, Petersen RC, Piguet O, Pijnenburg YA, Puca AA, Rademakers R, Rainero I, Reus LM, Richardson AM, Riemenschneider M, Rogaeva E, Rogelj B, Rollinson S, Rosen H, Rossi G, Rowe JB, Rubino E, Ruiz A, Salvi E, Sanchez-Valle R, Sando SB, Santillo AF, Saxon JA, Schlachetzki JC, Scholz SW, Seelaar H, Seeley WW, Serpente M, Sorbi S, Sordon S, St George-Hyslop P, Thompson JC, Van Broeckhoven C, Van Deerlin VM, Van der Lee SJ, Van Swieten J, Tagliavini F, van der Zee J, Veronesi A, Vitale E, Waldo ML, Yokoyama JS, Nalls MA, Momeni P, Singleton AB, Hardy J, Escott-Price V.
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| Am J Hum Genet. Jul 11;111(7):1316-1329. doi: 10.1016/j.ajhg.2024.05.017. Epub 2024 Jun 17 2024
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| 2 | DNAJA2, MAPT
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| Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.
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| Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.
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| Nat Struct Mol Biol 25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30.
2018
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| 3 | CX3CL1, CX3CR1, MAPT
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| Absence of CX3CR1 impairs the internalization of Tau by microglia.
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| Bolós M, Llorens-Martín M, Perea JR, Jurado-Arjona J, Rábano A, Hernández F, Avila J.
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| Mol Neurodegener. Aug 15;12(1):59. doi: 10.1186/s13024-017-0200-1 2017
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| 4 | DYRK1A, MAPT, SNCA
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| Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A.
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| Kay LJ, Smulders-Srinivasan TK, Soundararajan M.
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| Adv Protein Chem Struct Biol. 105:127-71. doi: 10.1016/bs.apcsb.2016.07.001. Epub 2016 Aug 9 2016
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| 5 | MAPT, POLDIP2
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| Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition.
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| Kim Y, Park H, Nah J, Moon S, Lee W, Hong SH, Kam TI, Jung YK.
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| Biochem Biophys Res Commun 462(2):112-8. doi: 10.1016/j.bbrc.2015.04.084. Epub 2015 Apr 27.
2015
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| 6 | MAPT, NUP62, PSEN1
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| Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation.
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| Tung YT, Wang BJ, Hsu WM, Hu MK, Her GM, Huang WP, Liao YF.
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| Mol Neurobiol 49(1):10-27. doi: 10.1007/s12035-013-8482-y. Epub 2013 Jun 23.
2014
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| 7 | MAPT, STUB1
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| Involvement of endoplasmic reticulum stress in tauopathy.
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| Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M.
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| Biochem Biophys Res Commun 430(2):500-4. doi: 10.1016/j.bbrc.2012.12.007. Epub 2012 Dec 10.
2013
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| 8 | MAPT, YWHAZ
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| Interaction of 14-3-3ζ with microtubule-associated protein tau within Alzheimer's disease neurofibrillary tangles.
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| Qureshi HY, Li T, MacDonald R, Cho CM, Leclerc N, Paudel HK.
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| Biochemistry 52(37):6445-55. doi: 10.1021/bi400442d. Epub 2013 Sep 4.
2013
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| 9 | MAPT, NMNAT2, PPP2CA
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| Nmnat2 attenuates Tau phosphorylation through activation of PP2A.
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| Cheng XS, Zhao KP, Jiang X, Du LL, Li XH, Ma ZW, Yao J, Luo Y, Duan DX, Wang JZ, Zhou XW.
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| J Alzheimers Dis 36(1):185-95. doi: 10.3233/JAD-122173.
2013
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| 10 | GSK3B, MAPT, NUB1
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| NUB1 modulation of GSK3β reduces tau aggregation.
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| Richet E, Pooler AM, Rodriguez T, Novoselov SS, Schmidtke G, Groettrup M, Hanger DP, Cheetham ME, van der Spuy J.
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| Hum Mol Genet 21(24):5254-67. doi: 10.1093/hmg/dds376. Epub 2012 Sep 10.
2012
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| 11 | MAPT
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| Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.
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| Iijima-Ando K, Sekiya M, Maruko-Otake A, Ohtake Y, Suzuki E, Lu B, Iijima KM.
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| PLoS Genet 8(8):e1002918. doi: 10.1371/journal.pgen.1002918. Epub 2012 Aug 30.
2012
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| 12 | MAPT
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| Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
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| Mondragón-Rodríguez S, Trillaud-Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, Boehm J.
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| J Biol Chem 287(38):32040-53. doi: 10.1074/jbc.M112.401240. Epub 2012 Jul 25.
2012
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| 13 | FUS, MAPT
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| Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.
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| Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D.
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| EMBO Rep 13(8):759-64. doi: 10.1038/embor.2012.90. Epub 2012 Jun 19.
2012
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| 14 | MAPT
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| Fibril-forming motifs are essential and sufficient for the fibrillization of human Tau.
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| Meng SR, Zhu YZ, Guo T, Liu XL, Chen J, Liang Y.
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| PLoS One 7(6):e38903. doi: 10.1371/journal.pone.0038903. Epub 2012 Jun 11.
2012
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| 15 | MAPT
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| Trans-cellular propagation of Tau aggregation by fibrillar species.
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| Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI.
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| J Biol Chem 287(23):19440-51. doi: 10.1074/jbc.M112.346072. Epub 2012 Mar 29.
2012
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| 16 | C9orf72, FTDP17, FTDU17, GRN, MAPT
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| Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics.
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| Whitwell JL, Weigand SD, Boeve BF, Senjem ML, Gunter JL, DeJesus-Hernandez M, Rutherford NJ, Baker M, Knopman DS, Wszolek ZK, Parisi JE, Dickson DW, Petersen RC, Rademakers R, Jack CR Jr, Josephs KA.
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| Brain 135(Pt 3):794-806. doi: 10.1093/brain/aws001. 2012
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| 17 | MAPT
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| Structural and functional characterization of H2 haplotype MAPT promoter: unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease.
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| Maloney B, Lahiri DK.
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| Gene 501(1):63-78. doi: 10.1016/j.gene.2012.01.049. Epub 2012 Jan 30.
2012
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| 18 | MAPT
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| Human tau may modify glucocorticoids-mediated regulation of cAMP-dependent kinase and phosphorylated cAMP response element binding protein.
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| Liu Y, Su Y, Sun S, Wang T, Qiao X, Li H, Run X, Liang Z.
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| Neurochem Res 37(5):935-47. doi: 10.1007/s11064-011-0686-9.
2012
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| 19 | MAPT
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| Tau acts as an independent genetic risk factor in pathologically proven PD.
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| Charlesworth G, Gandhi S, Bras JM, Barker RA, Burn DJ, Chinnery PF, Gentleman SM, Guerreiro R, Hardy J, Holton JL, Lees A, Morrison K, Sheerin UM, Williams N, Morris H, Revesz T, Wood NW.
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| Neurobiol Aging 33(4):838.e7-11. doi: 10.1016/j.neurobiolaging.2011.11.001. Epub 2012 Jan 4.
2012
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| 20 | MAPT
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| Tau's role in the developing brain: implications for intellectual disability.
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| Sapir T, Frotscher M, Levy T, Mandelkow EM, Reiner O.
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| Hum Mol Genet 21(8):1681-92. doi: 10.1093/hmg/ddr603. Epub 2011 Dec 21.
2012
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| 21 | DYRK1A, MAPT, SRSF6
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| Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.
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| Yin X, Jin N, Gu J, Shi J, Zhou J, Gong CX, Iqbal K, Grundke-Iqbal I, Liu F.
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| J Biol Chem 287(36):30497-506. doi: 10.1074/jbc.M112.355412. Epub 2012 Jul 5.
2012
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| 22 | CDC37, MAPT, TARDBP
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| Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.
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| Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA.
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| J Biol Chem 287(29):24814-20. doi: 10.1074/jbc.M112.367268. Epub 2012 Jun 6.
2012
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| 23 | MAPT, MARK2
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| Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.
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| Iijima-Ando K, Sekiya M, Maruko-Otake A, Ohtake Y, Suzuki E, Lu B, Iijima KM.
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| PLoS Genet 8(8):e1002918. doi: 10.1371/journal.pgen.1002918. Epub 2012 Aug 30.
2012
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| 24 | MAPT
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| MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies.
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| Trabzuni D, Wray S, Vandrovcova J, Ramasamy A, Walker R, Smith C, Luk C, Gibbs JR, Dillman A, Hernandez DG, Arepalli S, Singleton AB, Cookson MR, Pittman AM, de Silva R, Weale ME, Hardy J, Ryten M.
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| Hum Mol Genet 21(18):4094-103. doi: 10.1093/hmg/dds238.
2012
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| 25 | HTRA1, MAPT
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| Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
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| Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, Kaiser M, Huber R, Clausen T, Ehrmann M.
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| J Biol Chem 287(25):20931-41. doi: 10.1074/jbc.M111.316232. Epub 2012 Apr 25.
2012
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| 26 | CDC37, MAPT
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| The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.
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| Jinwal UK, Trotter JH, Abisambra JF, Koren J 3rd, Lawson LY, Vestal GD, O'Leary JC 3rd, Johnson AG, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA.
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| J Biol Chem 286(19):16976-83. Epub 2011 Mar 2.
2011
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| 27 | CALM1, MAPT
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| Tau regulates the subcellular localization of calmodulin.
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| Barreda EG, Avila J.
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| Biochem Biophys Res Commun 408(3):500-4. Epub 2011 Apr 21.
2011
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| 28 | EGR1, MAPT
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| Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain.
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| Lu Y, Li T, Qureshi HY, Han D, Paudel HK.
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| J Biol Chem 286(23):20569-81. Epub 2011 Apr 13. 2011
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| 29 | MAPT, PCBP2, SRSF4
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| An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia.
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| Wang Y, Wang J, Gao L, Stamm S, Andreadis A.
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| Gene 485(2):130-8. doi: 10.1016/j.gene.2011.06.020. Epub 2011 Jun 30.
2011
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| 30 | GSK3B, MAPT
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| GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent manner.
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| Llorens-Martín M, López-Doménech G, Soriano E, Avila J.
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| PLoS One 6(11):e27686. doi: 10.1371/journal.pone.0027686. Epub 2011 Nov 14.
2011
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| 31 | MAPT
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| Salivary tau species are potential biomarkers of Alzheimer's disease.
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| Shi M, Sui YT, Peskind ER, Li G, Hwang H, Devic I, Ginghina C, Edgar JS, Pan C, Goodlett DR, Furay AR, Gonzalez-Cuyar LF, Zhang J.
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| J Alzheimers Dis 27(2):299-305. doi: 10.3233/JAD-2011-110731.
2011
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| 32 | HSPB6, MAPT, YWHAZ
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| Properties of the monomeric form of human 14-3-3ζ protein and its interaction with tau and HspB6.
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| Sluchanko NN, Sudnitsyna MV, Seit-Nebi AS, Antson AA, Gusev NB.
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| Biochemistry 50(45):9797-808. doi: 10.1021/bi201374s. Epub 2011 Oct 19.
2011
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| 33 | HSPB6, MAPT, YWHAZ
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| Phosphomimicking mutations of human 14-3-3ζ affect its interaction with tau protein and small heat shock protein HspB6.
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| Sluchanko NN, Sudnitsyna MV, Chernik IS, Seit-Nebi AS, Gusev NB.
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| Arch Biochem Biophys 506(1):24-34. doi: 10.1016/j.abb.2010.11.003. Epub 2010 Nov 20.
2011
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| 34 | FKBP4, MAPT
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| A role for FKBP52 in Tau protein function.
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| Chambraud B, Sardin E, Giustiniani J, Dounane O, Schumacher M, Goedert M, Baulieu EE.
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| Proc Natl Acad Sci U S A 107(6):2658-63. Epub 2010 Jan 25.PMID: 20133804 2010
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| 35 | MAPT
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| Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
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| Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB.
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| PLoS Genet 6(7):e1001026.PMID: 20664788 2010
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| 36 | DEL17Q21, MAPT
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| Clinical and molecular characterization of 17q21.31 microdeletion syndrome in 14 French patients with mental retardation.
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| Dubourg C, Sanlaville D, Doco-Fenzy M, Le Caignec C, Missirian C, Jaillard S, Schluth-Bolard C, Landais E, Boute O, Philip N, Toutain A, David A, Edery P, Moncla A, Martin-Coignard D, Vincent-Delorme C, Mortemousque I, Duban-Bedu B, Drunat S, Beri M, Mosser J, Odent S, David V, Andrieux J.
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| Eur J Med Genet ur J Med Genet. 2010 Nov 20. [Epub ahead of print]PMID: 21094706 2010
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| 37 | KLC1, MAPT
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| Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.
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| Falzone TL, Gunawardena S, McCleary D, Reis GF, Goldstein LS.
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| Hum Mol Genet 19(22):4399-408. Epub 2010 Sep 3.
2010
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| 38 | DEL17Q21, MAPT
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| Phenotypic expansion and further characterisation of the 17q21.31 microdeletion syndrome.
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| Tan TY, Aftimos S, Worgan L, Susman R, Wilson M, Ghedia S, Kirk EP, Love D, Ronan A, Darmanian A, Slavotinek A, Hogue J, Moeschler JB, Ozmore J, Widmer R, Savarirayan R, Peters G.
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| J Med Genet 46(7):480-9. Epub 2009 May 15.
2009
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| 39 | MAPT
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| H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers.
|
| Canu E, Boccardi M, Ghidoni R, Benussi L, Testa C, Pievani M, Bonetti M, Binetti G, Frisoni GB.
|
| Eur J Hum Genet 17(3):287-94. Epub 2008 Oct 15.
2009
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| 40 | BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
|
| Microtubule assembly, organization and dynamics in axons and dendrites.
|
| Conde C, Caceres A.
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| Nat Rev Neurosci. 10(5):319-32. 2009
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| 41 | FTDP17, MAPT
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| Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro.
|
| Han D, Qureshi HY, Lu Y, Paudel HK.
|
| J Biol Chem 284(20):13422-33. Epub 2009 Mar 19.
2009
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| 42 | DEL17Q21, MAPT
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| Clinical and molecular delineation of the 17q21.31 microdeletion syndrome.
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| Koolen DA, Sharp AJ, Hurst JA, Firth HV, Knight SJ, Goldenberg A, Saugier-Veber P, Pfundt R, Vissers LE, Destrée A, Grisart B, Rooms L, Van der Aa N, Field M, Hackett A, Bell K, Nowaczyk MJ, Mancini GM, Poddighe PJ, Schwartz CE, Rossi E, De Gregori M, Antonacci-Fulton LL, McLellan MD 2nd, Garrett JM, Wiechert MA, Miner TL, Crosby S, Ciccone R, Willatt L, Rauch A, Zenker M, Aradhya S, Manning MA, Strom TM, Wagenstaller J, Krepischi-Santos AC, Vianna-Morgante AM, Rosenberg C, Price SM, Stewart H, Shaw-Smith C, Brunner HG, Wilkie AO, Veltman JA, Zuffardi O, Eichler EE, de Vries BB.
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| J Med Genet 45(11):710-20. Epub 2008 Jul 15.
2008
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| 43 | FTDP17, MAPT
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| FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action.
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| LeBoeuf AC, Levy SF, Gaylord M, Bhattacharya A, Singh AK, Jordan MA, Wilson L, Feinstein SC.
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| J Biol Chem 283(52):36406-15. Epub 2008 Oct 21.
2008
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| 44 | FTDP17, MAPT
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| The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family.
|
| Spina S, Farlow MR, Unverzagt FW, Kareken DA, Murrell JR, Fraser G, Epperson F, Crowther RA, Spillantini MG, Goedert M, Ghetti B.
|
| Brain 131(Pt 1):72-89. Epub 2007 Dec 7.PMID: 18065436 2008
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| 45 | MAPT
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| Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia.
|
| Sundar PD, Yu CE, Sieh W, Steinbart E, Garruto RM, Oyanagi K, Craig UK, Bird TD, Wijsman EM, Galasko DR, Schellenberg GD.
|
| Hum Mol Genet 16(3):295-306. Epub 2006 Dec 21. 2007
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| 46 | CRHR1,DUP17Q21,MAPT
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| A 17q21.31 microduplication, reciprocal to the newly described 17q21.31 microdeletion, in a girl with severe psychomotor developmental delay and dysmorphic craniofacial features.
|
| Kirchhoff M, Bisgaard AM, Duno M, Hansen FJ, Schwartz M.
|
| Eur J Med Genet 50: 256-263 2007
|
| 47 | FTDP17, MAPT
|
| TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
|
| Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, Oda T.
|
| Biochem Biophys Res Commun 351(3):602-11. Epub 2006 Oct 30.
2006
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| 48 | DYT3, FTDP17, FTDU17, FXTAS, LRRK2, MAPT, PARK1, PARK4, PARK5, PARK6, PARK7, PARK8, PINK1, PRKN, PSRP, SNCA, UCHL1
|
| Genetics of Parkinson disease: paradigm shifts and future prospects.
|
| Farrer MJ.
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| Nat Rev Genet 7(4):306-18. 2006
|
| 49 | MAPT
|
| Extracellular tau is toxic to neuronal cells.
|
| G—mez-Ramos A, D’az-Hern‡ndez M, Cuadros R, Hern‡ndez F, Avila J.
|
| FEBS Lett 580(20):4842-50. Epub 2006 Aug 8. 2006
|
| 50 | CDK5,MAPT
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| Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.
|
| Sengupta A, Novak M, Grundke-Iqbal I, Iqbal K.
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| FEBS Lett 580(25):5925-33. Epub 2006 Oct 5. 2006
|
| 51 | MAPT
|
| PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.
|
| Liu F, Liang Z, Shi J, Yin D, El-Akkad E, Grundke-Iqbal I, Iqbal K, Gong CX.
|
| FEBS Lett 580(26):6269-74. Epub 2006 Oct 24. 2006
|
| 52 | MAPT, DM1
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| Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1.
|
| Leroy O, Wang J, Maurage CA, Parent M, Cooper T, BuŽe L, Sergeant N, Andreadis A, Caillet-Boudin ML.
|
| Biochim Biophys Acta 1762(4):460-7. Epub 2005 Dec 29. 2006
|
| 53 | FTDP17, MAPT
|
| Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease.
|
| Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio EH, Ghetti B, Murrell JR, Delisle MB, Mirra S, Crain B, Zolo P, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, Mackenzie J, Khan N, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Mann DM.
|
| Neuropathol Appl Neurobiol 32(4):374-87. 2006
|
| 54 | APP, MAPT
|
| Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.
|
| Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.
|
| Proc Natl Acad Sci U S A. 103(6):1953-8. 2006
|
| 55 | DEL17Q21,FTDP17,FTDU17,GRN,MAPT
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| Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region.
|
| Cruts M, Rademakers R, Gijselinck I, van der Zee J, Dermaut B, de Pooter T, de Rijk P, Del-Favero J, van Broeckhoven C.
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| Hum Mol Genet 14(13):1753-62. Epub 2005 May 11. 2005
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| 56 | MAPT
|
| Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration.
|
| Pittman AM, Myers AJ, Abou-Sleiman P, Fung HC, Kaleem M, Marlowe L, Duckworth J, Leung D, Williams D, Kilford L, Thomas N, Morris CM, Dickson D, Wood NW, Hardy J, Lees AJ, de Silva R.
|
| J Med Genet 42(11):837-46. Epub 2005 Mar 25. 2005
|
| 57 | MAPT,PRDX6,STH
|
| Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6.
|
| Gao L, Tse SW, Conrad C, Andreadis A.
|
| J Biol Chem 280(47):39268-72. Epub 2005 Sep 26. 2005
|
| 58 | MAPT, FTDP17
|
| Familial autosomal dominant cortico-basal degeneration with the P301S mutation in the tau gene: an example of phenotype variability.
|
| Casseron W, Azulay JP, Guedj E, Gastaut JL, Pouget J.
|
| J Neurol 252(12):1546-8. No abstract available. 2005
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| 59 | MAPT
|
| Tau suppression in a neurodegenerative mouse model improves memory function.
|
| Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH.
|
| Science. 309(5733):476-81 2005
|
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| CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
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| Hum Mol Genet 13(7):703-14. Epub 2004 Feb 12. 2004
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| 61 | MAPT
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| Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases.
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| Schraen-Maschke S, Dhaenens CM, Delacourte A, Sablonniere B.
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| Neurobiol Dis 15(3):449-60. 2004
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| 62 | C1QL1, CRHR1, FTDP17, MAPT, PSRP, SPPL2C
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| The structure of the tau haplotype in controls and in progressive supranuclear palsy.
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| Pittman AM, Myers AJ, Duckworth J, Bryden L, Hanson M, Abou-Sleiman P, Wood NW, Hardy J, Lees A, De Silva R.
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| Hum Mol Genet 13(12):1267-74. Epub 2004 Apr 28. 2004
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| 63 | MAPT
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| Linkage Disequilibrium and Association of MAPT H1 in Parkinson Disease.
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| Skipper L, Wilkes K, Toft M, Baker M, Lincoln S, Hulihan M, Ross OA, Hutton M, Aasly J, Farrer M.
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| 64 | MAPT
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| The role of tau (MAPT) in frontotemporal dementia and related tauopathies.
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| Rademakers R, Cruts M, van Broeckhoven C.
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| Hum Mutat 24(4):277-95. 2004
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| 65 | MAPT
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| Tau gene (MAPT) sequence variation among primates.
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| Gene. 341:313-22. 2004
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| 66 | FTDP17, MAPT, TRA2B
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| Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta.
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| Jiang Z, Tang H, Havlioglu N, Zhang X, Stamm S, Yan R, Wu JY.
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| J Biol Chem 278(21):18997-9007. Epub 2003 Mar 20. 2003
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| 67 | FTDP17,MAPT
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| A case of dementia parkinsonism resembling progressive supranuclear palsy due to mutation in the tau protein gene.
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| Arch Neurol 60(10):1454-6. 2003
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| 68 | MAPT
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| Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro.
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| Ksiezak-Reding H, Pyo HK, Feinstein B, Pasinetti GM.
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| Biochim Biophys Acta. 1639(3):159-68 2003
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| 69 | MAPT
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| Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau.
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| Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J.
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| J Neurosci. 22(3):698-707. 2002
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| 70 | MAPT
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| polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease.
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| Conrad C, Vianna C, Freeman M, Davies P.
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| Proc Natl Acad Sci U S A. 99(11):7751-6. 2002
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| 71 | MAPT
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| Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1.
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| Sergeant N, Sablonniere B, Schraen-Maschke S, Ghestem A, Maurage CA, Wattez A, Vermersch P, Delacourte A.
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| Hum Mol Genet 10(19):2143-55. 2001
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| 72 | MAPT
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| A genomic sequence analysis of the mouse and human microtubule-associated protein tau.
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| Poorkaj P, Kas A, D'Souza I, Zhou Y, Pham Q, Stone M, Olson MV, Schellenberg GD.
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| Mamm Genome 12(9):700-12. 2001
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| 73 | MAPT
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| S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease.
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| Yu WH, Fraser PE.
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| J Neurosci. 21(7):2240-6.Click here to read 2001
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| 74 | MAPT
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| Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
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| Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E.
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| Science. 11520987 2001
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| 75 | MAPT
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| Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure.
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| von Bergen M, Friedhoff P, Biernat J, Heberle J, Mandelkow EM, Mandelkow E.
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| Proc Natl Acad Sci U S A 97(10):5129-34. 2000
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| 76 | FTDP17,MAPT
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| Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).
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| Spillantini MG, Van Swieten JC, Goedert M.
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| Neurogenetics 2(4):193-205. 2000
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| 77 | FTDP17,MAPT
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| A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto).
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| Yasuda M, Takamatsu J, D'Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Varani G, Iwatsubo T, Goedert M, Schellenberg DG, Tanaka C.
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| Ann Neurol 47(4):422-9. 2000
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| 78 | FTDP17,MAPT
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| Mutation-dependent aggregation of tau protein and its selective depletion from the soluble fraction in brain of P301L FTDP-17 patients.
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| Rizzu P, Joosse M, Ravid R, Hoogeveen A, Kamphorst W, van Swieten JC, Willemsen R, Heutink P.
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| Hum Mol Genet 9(20):3075-82. 2000
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| 79 | MAPT
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| 14-3-3zeta is an effector of tau protein phosphorylation.
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| Hashiguchi M, Sobue K, Paudel HK.
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| J Biol Chem. 275(33):25247-54.Click here to read 2000
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| 80 | MAPT
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| Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
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| Lewis, J.; McGowan, E.; Rockwood, J.; Melrose, H.; Nacharaju, P.; Van Slegtenhorst, M.; Gwinn-Hardy, K.; Murphy, M. P.; Baker, M.; Yu, X.; Duff, K.; Hardy, J.; Corral, A.; Lin, W.-L.; Yen, S.-H.; Dickson, D. W.; Davies, P.; Hutton, M.
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| Nature Genet. 25: 402-405 2000
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| 81 | FTDP17,MAPT
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| High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the netherlands.
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| Rizzu P, et al.
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| Am J Hum Genet 64(2):414-21. 1999
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| 82 | MAPT, PSRP
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| Association of an extended haplotype in the tau gene with progressive supranuclear palsy.
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| Baker M, et al.
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| Hum Mol Genet 8(4):711-5. 1999
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| 83 | FTDP17,MAPT
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| Tau gene mutation in familial progressive subcortical gliosis.
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| Goedert M, et al.
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| Nat Med 5(4):454-7. 1999
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| 84 | FTDP17,MAPT
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| A distinct familial presenile dementia with a novel missense mutation in the tau gene.
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| Iijima M, et al.
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| Neuroreport 10(3):497-501. 1999
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| 85 | FTDP17,MAPT
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| Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements.
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| D'Souza I, et al.
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| Proc Natl Acad Sci U S A 96(10):5598-603. 1999
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| 86 | FTDP17,MAPT,PSRP
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| The tangled biology of tau.
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| Proc Natl Acad Sci U S A 96(13):7120-1. No abstract available 1999
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| 87 | MAPT
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| Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.
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| Varani L, et al.
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| Proc Natl Acad Sci U S A 96(14):8229-34. 1999
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| 88 | MAPT, PIN1
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| The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein.
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| Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP.
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| Nature 399(6738):784-8. 1999
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| 89 | MAPT, PSRP
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| A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy.
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| Delisle MB, et al.
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| Acta Neuropathol (Berl) 98(1):62-77 1999
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| 90 | FTDP17,MAPT
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| Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21.
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| Froelich S, et al.
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| Genomics 60(2):129-36 1999
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| 91 | MAPT
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| Expression of tau proteins and tubulin in extraskeletal myxoid chondrosarcoma, chordoma, and other chondroid tumors.
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| Hu B, et al.
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| Am J Clin Pathol 112(2):189-93 1999
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| 92 | FTDP17,MAPT
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| A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration.
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| Yasuda M, Kawamata T, Komure O, Kuno S, D'Souza I, Poorkaj P, Kawai J, Tanimukai S, Yamamoto Y, Hasegawa H, Sasahara M, Hazama F, Schellenberg GD, Tanaka C.
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| Neurology 53(4):864-8 1999
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| 93 | FTDP17,MAPT
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| FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion.
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| Yen S, Easson C, Nacharaju P, Hutton M, Yen SH.
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| FEBS Lett 461(1-2):91-5 1999
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| 94 | MAPT
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| Mutation screening of the tau gene in patients with early-onset Alzheimer's disease.
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| Roks G, Dermaut B, Heutink P, Julliams A, Backhovens H, Van de Broeck M, Serneels S, Hofman A, Van Broeckhoven C, van Duijn CM, Cruts M.
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| Neurosci Lett 277(2):137-9. 1999
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| 95 | MAPT
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| Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively exon 10 isoforms.
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| Sergeant N, Wattez A, Delacourte A.
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| J Neurochem 72(3):1243-9. 1999
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| 96 | MAPT
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| alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.
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| Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R.
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| J Biol Chem. 274(36):25481-9. 1999
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| 97 | MAPT
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| Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein.
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| Spittaels, K.; van den Haute, C.; van Dorpe, J.; Bruynseels, K.; Vandezande, K.; Laenen, I.; Geerts, H.; Mercken, M.; Sciot, R.; van Lommel, A.; Loos, R.; van Leuven, F.
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| Am. J. Path. 155: 2153-2165 1999
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| 98 | FTDP17,MAPT
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| Tau is a candidate gene for chromosome 17 frontotemporal dementia.
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| Poorkaj P, et al.
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| Ann Neurol 43 : 815-825. 1998
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| 99 | FTDP17,MAPT
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| Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism.
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| Dumanchin C, et al.
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| Hum Mol Genet 7 : 1825-1829. 1998
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| 100 | FTDP17,MAPT
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| Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
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| Hong M, et al.
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| Science 282 : 1914-1917. 1998
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| 101 | MAPT, PSEN1
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| Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.
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| Takashima A, Murayama M, Murayama O, Kohno T, Honda T, Yasutake K, Nihonmatsu N, Mercken M, Yamaguchi H, Sugihara S, Wolozin B.
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| Proc Natl Acad Sci U S A. 95(16):9637-41. 1998
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| 102 | MAPT
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| The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains.
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| Chau MF, Radeke MJ, de Inés C, Barasoain I, Kohlstaedt LA, Feinstein SC.
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| Biochemistry. 37(51):17692-703. 1998
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| 103 | MAPT
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| Two-dimensional characterization of paired helical filament-tau from Alzheimer's disease: demonstration of an additional 74-kDa component and age-related biochemical modifications.
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| Sergeant N, David JP, Goedert M, Jakes R, Vermersch P, Buee L, Lefranc D, Wattez A, Delacourte A.
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| J Neurochem 69(2):834-44. 1997
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| 104 | MAPT
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| BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.
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| Elliott E, Tsvetkov P, Ginzburg I.
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| J Biol Chem. 282(51):37276-84. 1997
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| 105 | MAPT
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| Localization of the gene for rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration to chromosome 17q21.
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| Wijker M, et al.
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| Hum Mol Genet 5 : 151-154. 1996
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| 106 | MAPT
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| beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.
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| Giaccone G, Pedrotti B, Migheli A, Verga L, Perez J, Racagni G, Smith MA, Perry G, De Gioia L, Selvaggini C, Salmona M, Ghiso J, Frangione B, Islam K, Bugiani O, Tagliavini F.
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| Am J Pathol. 148(1):79-87 1996
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| 107 | MAPT
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| Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins.
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| Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV.
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| Exp Neurol. 138(2):252-60. 1996
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| 108 | MAPT
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| ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.
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| Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ.
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| Neurosci Lett. 192(3):209-12.Click here to read 1995
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| 109 | MAPT
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| Structure and novel exons of the human tau gene.
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| Andreadis A, et al.
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| Biochemistry 31 : 10626-10633. 1992
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| 110 | MAPT
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| Molecular characterization of a genomic clone encoding the microtubule-associated protein tau (MTBT1).
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| Watkins PC, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 2011. 1991
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| 111 | MAPT
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| Tau-ubiquitin protein conjugates in a human cell line.
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| Mesco ER, Timiras PS.
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| Mech Ageing Dev. 61(1):1-9. 1991
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| 112 | CALM1, MAPT
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| Calmodulin binds to a tubulin binding site of the microtubule-associated protein tau.
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| Padilla R, Maccioni RB, Avila J.
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| Mol Cell Biochem. 97(1):35-41. 1990
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| 113 | MAPT
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| Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease.
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| Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA.
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| Neuron 3(4):519-26. 1989
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| 114 | MAPT
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| Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.
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| Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA.
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| EMBO J 8(2):393-9. 1989
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| 115 | MAPT
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| Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II.
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| 116 | MAPT
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| Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21.
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| Donlon TA, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 607. 1987
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| 117 | MAP2, MAPT
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| Identification of cDNA clones for the human microtubule associated protein tau and chromosomal localization of the genes for tau and microtubule associated protein 2.
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| Neve RL, et al.
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| Brain Res 387 : 271-280. 1986
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| 118 | MAPT
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| Interaction between microtubule-associated protein tau and spectrin.
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| Carlier MF, Simon C, Cassoly R, Pradel LA.
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| Biochimie 66(4):305-11. 1984
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| 119 | MAPT
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| A protein factor essential for microtubule assembly.
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