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FLASH GENE

Symbol

MPO

contributors: mct - updated : 28-11-2017

HGNC name	myeloperoxidase
HGNC id	7218

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MPOD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in children with hypercholesterolemia tumoral       loss of function in myelofibrosis (MF) patients with MPO deficiency is associated a homozygous CALR mutation and also deficiency in eosinophilic peroxidase (EPX constitutional       gain of function is associated with the development of obesity

Susceptibility

to Kawasaki disease (KD) to gastric cancer

Variant & Polymorphism SNP	G allele of MPO -463G>A polymorphism is a potential genetic marker for KD risk
	MPO gene polymorphism MPO-463 G/G genotype is associated with susceptibility of gastric cancer

Candidate gene
Marker	may potentially be used as an imaging biomarker of cerebral aneurysm instability
	is an early biomarker of inflammation associated with cardiovascular disease (CVD) risk in obese children at the prepubertal age
Therapy target
	System Type Disorder Pubmed immunology inflammatory   peroxidase inhibitors may have therapeutic potential for the treatment of angiogenesis related diseases driven by inflammation cardiovascular rythm   may serve as a potential new target of treatment in atrial fibrillation

ANIMAL & CELL MODELS

	Mpo-deficient mice were protected from atrial fibrillation, which was reversed when MPO was restored
	Mpo deficiency upregulates the expression of several proinflammatory cytokines and chemokines in mouse neutrophils
	in diabetic rat aortas, both Mpo expresion and NADPH oxidase activity were increased while the endothelial function was simultaneously impaired