| Symbol
| MPO
| contributors: mct - updated : 28-11-2017
|
| HGNC name
| myeloperoxidase
|
| HGNC id
| 7218
|
| corresponding disease(s)
|
MPOD
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
|
in children with hypercholesterolemia  | | tumoral
|
|
|
| loss of function
| |
in myelofibrosis (MF) patients with MPO deficiency is associated a homozygous CALR mutation and also deficiency in eosinophilic peroxidase (EPX | | constitutional
|
|
|
| gain of function
| |
is associated with the development of obesity | |
| Susceptibility
|
to Kawasaki disease (KD) to gastric cancer |
| Variant & Polymorphism
SNP
| G allele of MPO -463G>A polymorphism is a potential genetic marker for KD risk |
|
MPO gene polymorphism MPO-463 G/G genotype is associated with susceptibility of gastric cancer |
| 
|
Candidate gene
| Marker
| may potentially be used as an imaging biomarker of cerebral aneurysm instability | |
is an early biomarker of inflammation associated with cardiovascular disease (CVD) risk in obese children at the prepubertal age | | Therapy target
| | |
|
| System | Type | Disorder | Pubmed |
|---|
| immunology | inflammatory | | |
| peroxidase inhibitors may have therapeutic potential for the treatment of angiogenesis related diseases driven by inflammation | | cardiovascular | rythm | | |
| may serve as a potential new target of treatment in atrial fibrillation |
| |
|
| Mpo-deficient mice were protected from atrial fibrillation, which was reversed when MPO was restored | |
Mpo deficiency upregulates the expression of several proinflammatory cytokines and chemokines in mouse neutrophils |
|
in diabetic rat aortas, both Mpo expresion and NADPH oxidase activity were increased while the endothelial function was simultaneously impaired |