| basic FUNCTION
| involved in oxygen dependent mechanism of phagocytosis and in myeloid differentiation |
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contributes critically to O2-dependent neutrophil antimicrobial activity |
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implicated in atherosclerosis and cholesterol homeostasis |
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crucial prerequisite for structural remodeling of the myocardium, leading to an increased vulnerability to atrial fibrillation  |
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acts as a major downstream mediator of atrial fibrosis and atrial arrhythmogeneity |
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intimately involved in the pathophysiology of atrial fibrillation |
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is required for neutrophil extracellular traps (NETs) formation |
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is involved in a multitude of inflammatory processes involving oxidative modification of soluble components and cellular surfaces |
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plays a key role in promoting atherosclerosis via oxidative stress by modification of both high- and low-density lipoprotein and production of other bioactive molecules |
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MPO is unique in its capacity to oxidize chloride at physiologic pH to produce hypochlorous acid (HOCl), a potent microbicide that contributes to neutrophil-mediated host defense against infection |
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MPO, via its catalytic activity, inhibits the generation of adaptive immunity by suppressing dendritic cells (DCs) activation, Ag uptake/processing, and migration to lymph nodes (LNs) to limit pathological tissue inflammation |
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abundant hemoprotein expressed by neutrophil granulocytes that is recognized to play an important role in the development of vascular diseases |
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uses hydrogen peroxide generated by the oxidative burst of neutrophils to produce an array of antimicrobial oxidants |
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has both potent microbicidal and, upon binding to the vessel wall, pro-inflammatory properties |
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role for myeloperoxidase-dependent lipid peroxidation |
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MPO -dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils |
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MPO may contribute importantly to formation and rupture of cerebral aneurysms |
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important and previously unsuspected role for MPO and EPX as drivers of angiogenesis |
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chaperoned by calreticulin (CALR) in the endoplasmic reticulum |
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MPO and PRTN3 in neutrophils of Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) patients with active disease have a distinct pattern of histone modifications, which implicates epigenetic mechanisms in regulating expression of autoantigen genes |
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peroxidase enzymes, like MPO and EPX, may play a fundamental role in inhibiting TNFSF11-induced osteoclast differentiation at inflammatory sites of bone fracture and injury |
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the difference in MPO between women with abnormal and normal menstrual cycles and the upregulation of MPO before ovulation suggest that neutrophils and MPO are closely related to ovulation |
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is the major peroxidase enzyme in neutrophil granules and is implicated in contributing to inflammatory lung damage in cystic fibrosis |
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EPX and MPO are key contributors to cancer progression by augmenting pro-tumorigenic collagen production and angiogenesis |
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is synthesized by neutrophil and monocyte precursor cells and contributes to host defense by mediating microbial killing |
