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FLASH GENE
Symbol M6PR contributors: mct - updated : 30-05-2023
HGNC name mannose-6-phosphate receptor (cation dependent)
HGNC id 6752
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine M6pr
ortholog to rattus m6pr
Homologene
FAMILY Cation-dependent mannose-6-phosphate receptor family
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,organelle,lysosome
intracellular,nuclear envelope
text type 1 membrane protein
basic FUNCTION
  • mannose 6-phosphate receptor, cation dependent, targeting phosphorylated enzymes to lysosomes
  • involved in transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface
    • to lysosomes
  • selective M6PR down-regulation has a critical role in CD8(+) T cell survival
  • facilitates cellular uptake of M6P-bearing proteins, including serine-protease granzyme-B (Gzm-B) and has an important role in T-cell activation, migration and contraction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of cell surface of Golgi and late endosome membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding GGA1, GGA2 and GGA3
  • OCRL counteracted accumulation of M6PR in endosomes in an activity-dependent manner
  • RAB29 is essential for the integrity of the TGN and participates in the retrograde trafficking of M6PR
  • MTOR regulates M6PR transport and T-cell vulnerability to regulatory T cells controlling kinesin KIF13A
  • HSPA1A and M6PR negatively regulated APP processing and Abeta production
  • GIMAP5 promoted the transport of M6PR from the cytoplasm to the cell membrane, thereby inhibiting the enhancement of EMT-related PADI4
  • GIMAP5 promotes the degradation of Respiratory syncytial virus (RSV) and its receptor through interacting with M6PR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS