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FLASH GENE

Symbol

M6PR

contributors: mct - updated : 30-05-2023

HGNC name	mannose-6-phosphate receptor (cation dependent)
HGNC id	6752

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	9.28 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001414330 6 - 2322 NP_001401259 - 105 - 1995 7640295 NM_001414322 7 - 2432 NP_001401251 - 159 - 1995 7640295 NM_001414328 7 - 2481 NP_001401257 - 132 - 1995 7640295 NM_001414324 6 - 2283 NP_001401253 - 159 - 1995 7640295

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Reproductive female system ovary     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to murine M6pr
	ortholog to rattus m6pr

Homologene

FAMILY

Cation-dependent mannose-6-phosphate receptor family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
	intracellular,nuclear envelope
text	type 1 membrane protein

basic FUNCTION	mannose 6-phosphate receptor, cation dependent, targeting phosphorylated enzymes to lysosomes
	involved in transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface
	to lysosomes
	selective M6PR down-regulation has a critical role in CD8(+) T cell survival
	facilitates cellular uptake of M6P-bearing proteins, including serine-protease granzyme-B (Gzm-B) and has an important role in T-cell activation, migration and contraction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of cell surface of Golgi and late endosome membrane

INTERACTION

DNA

RNA

small molecule

protein	binding GGA1, GGA2 and GGA3
	OCRL counteracted accumulation of M6PR in endosomes in an activity-dependent manner
	RAB29 is essential for the integrity of the TGN and participates in the retrograde trafficking of M6PR
	MTOR regulates M6PR transport and T-cell vulnerability to regulatory T cells controlling kinesin KIF13A
	HSPA1A and M6PR negatively regulated APP processing and Abeta production
	GIMAP5 promoted the transport of M6PR from the cytoplasm to the cell membrane, thereby inhibiting the enhancement of EMT-related PADI4
	GIMAP5 promotes the degradation of Respiratory syncytial virus (RSV) and its receptor through interacting with M6PR

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS