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FLASH GENE

Symbol

LDHC

contributors: mct - updated : 15-05-2020

HGNC name	lactate dehydrogenase C
HGNC id	6544

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         escaping from transcriptional repression, resulting in significant expression levels in virtually all tumor types tested constitutional     --over   in placentas from pregnancies with IUGR

Susceptibility

to type 1 diabetes

Variant & Polymorphism other	association between the methylation status of CpG sites within the LDHC gene and the development of insulin autoantibodies in early childhood in children who are carriers of the highest type 1 diabetes risk genotype

Candidate gene
Marker	serum and exosomal LDHC may be an effective indicator for the diagnosis, efficacy evaluation, and monitoring the recurrence of breast cancer (BC)
Therapy target
	System Type Disorder Pubmed reproduction contraception   is the unique target for contraception in both males and females cancer     offers potential future for immunotherapy of different types of cancers

ANIMAL & CELL MODELS