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FLASH GENE
Symbol LDHC contributors: mct - updated : 15-05-2020
HGNC name lactate dehydrogenase C
HGNC id 6544
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
escaping from transcriptional repression, resulting in significant expression levels in virtually all tumor types tested
constitutional     --over  
in placentas from pregnancies with IUGR
Susceptibility to type 1 diabetes
Variant & Polymorphism other
  • association between the methylation status of CpG sites within the LDHC gene and the development of insulin autoantibodies in early childhood in children who are carriers of the highest type 1 diabetes risk genotype
  • Candidate gene
    Marker
  • serum and exosomal LDHC may be an effective indicator for the diagnosis, efficacy evaluation, and monitoring the recurrence of breast cancer (BC)
  • Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    is the unique target for contraception in both males and females
    cancer  
    offers potential future for immunotherapy of different types of cancers
    ANIMAL & CELL MODELS