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FLASH GENE

Symbol

LDHC

contributors: mct - updated : 15-05-2020

HGNC name	lactate dehydrogenase C
HGNC id	6544

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	39.77 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002301 8 splicing 1318 NP_002292 - 332 - 2017 28351304 variant 1 contains an upstream start of transcription and an alternatively spliced exon 1 NM_017448 8 splicing 2035 NP_059144 - 332 - 2017 28351304 variant 2 contains a downstream start of transcription and an alternatively spliced exon 1

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatozoa Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies	ortholog to murine Ldh3
	ortholog to rattus ldhc

Homologene

FAMILY	LDH/MDH superfamily
	LDH family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus

basic FUNCTION	catalyzing the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis
	in addition to its role in glycolysis, LDHC is likely part of a complex involved in ATP homeostasis that is disrupted in sperm lacking LDHC
	spermatozoa require LDHC for capacitation, motility, and fertilizing capacity
	sperm without LDHC were still able to convert lactate to pyruvate as mediated by LDHA that is tightly bound to the fibrous sheath
	expression levels of GAPDHS, PGK2 and LDHC in the spermatozoa were closely correlated with progressive sperm motility

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

LDHC is required for LDHA expression in the sperm, and this unique functional interaction between LDH family members supports lactate dehydrogenase activity in the sperm

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         escaping from transcriptional repression, resulting in significant expression levels in virtually all tumor types tested constitutional     --over   in placentas from pregnancies with IUGR

Susceptibility

to type 1 diabetes

Variant & Polymorphism other	association between the methylation status of CpG sites within the LDHC gene and the development of insulin autoantibodies in early childhood in children who are carriers of the highest type 1 diabetes risk genotype

Candidate gene
Marker	serum and exosomal LDHC may be an effective indicator for the diagnosis, efficacy evaluation, and monitoring the recurrence of breast cancer (BC)
Therapy target
	System Type Disorder Pubmed reproduction contraception   is the unique target for contraception in both males and females cancer     offers potential future for immunotherapy of different types of cancers

ANIMAL & CELL MODELS