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FLASH GENE

Symbol

KLK2

contributors: mct/npt - updated : 16-04-2020

HGNC name	kallikrein-related peptidase 2
HGNC id	6363

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       Fusion of KLK2 to ETV4 in prostate cancer results in the generation of an additional ETV4 exon, denoted exon 4a (Hermans 2008) tumoral     --over   in prostate cancer (Koistinen 2008) tumoral fusion       KLK2-FGFR2 fusion gene in metastatic prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene	produced and secreted in the prostate and have important applications in the diagnosis of prostate cancer (David 2002)
	potential target for tumor imaging and treatment in prostate cancer cells (Koistinen 2008)
Marker	biomarker potential for chromophobe renal cell carcinoma
Therapy target

ANIMAL & CELL MODELS