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FLASH GENE
Symbol KLK2 contributors: mct/npt - updated : 16-04-2020
HGNC name kallikrein-related peptidase 2
HGNC id 6363
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • serine protease with three alternatively spliced isoforms
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to KLK3
    Homologene
    FAMILY
  • kallikrein family
  • peptidase S1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • playing a role in prostate cancer susceptibility and this role may be realized at least in part by the induction of increases in its production (Nam 2006)
  • highly prostate-specific serine protease, which is mainly excreted into the seminal fluid (Pakkala 2007)
  • may mediate tumor growth and invasion by participating in proteolytic cascades (Koistinen 2008)
  • direct transcriptional target (Lawrence 2010)
  • KLK2 is a key serine protease in semen liquefaction and prostate cancer together with KLK3/prostate-specific antigen
  • alternative protein cleavage and glycosylation of KLK2 may correlate with the disease state, suggesting that KLK2 monitoring may increase the sensitivity and specificity of prostate cancer markers
  • KLK3, KLK4, KLK11, and KLK2, belong to the prostatic group of the KLKs, whose major physiological function is semen liquefaction during the fertilization process
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with protease inhibitor 6 in prostate cancer tissue
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KLK2 may cooperate with the AR coregulator,NCOA4, to enhance AR transactivation that may result in alteration of Prostate cancer formation
  • most likely it activates and complements chymotryptic KLK3 (prostate-specific antigen) in cleaving seminal clotting proteins, resulting in sperm liquefaction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    Fusion of KLK2 to ETV4 in prostate cancer results in the generation of an additional ETV4 exon, denoted exon 4a (Hermans 2008)
    tumoral     --over  
    in prostate cancer (Koistinen 2008)
    tumoral fusion      
    KLK2-FGFR2 fusion gene in metastatic prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • produced and secreted in the prostate and have important applications in the diagnosis of prostate cancer (David 2002)
  • potential target for tumor imaging and treatment in prostate cancer cells (Koistinen 2008)
    • Marker
  • biomarker potential for chromophobe renal cell carcinoma
    • Therapy target
    ANIMAL & CELL MODELS