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FLASH GENE
Symbol PYGM contributors: mct - updated : 10-01-2014
HGNC name phosphorylase, glycogen, muscle
HGNC id 9726
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine Pygm
ortholog to rattus pygm
Homologene
FAMILY
  • glycogen phosphorylase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing and regulating the breakdown of glycogen to glucose-1-phosphate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • two dimers associate into a tetramer to form the enzymatically active phosphorylase A
    • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
    • protein
  • ACTN3 potentially regulates PYGM activity by altering its level of phosphorylation
  • to activate RAC1 and consequently PYGM, PRKCQ phosphorylates ARHGEF6 in T cells
    • cell & other
    REGULATION
    Other allosterically activated by AMP
    allosterically inhibited by ATP, ADP, and glucose-6-phosphate
    ASSOCIATED DISORDERS
    corresponding disease(s) PYGM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS