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FLASH GENE
Symbol PYGM contributors: mct - updated : 10-01-2014
HGNC name phosphorylase, glycogen, muscle
HGNC id 9726
DNA
TYPE functioning gene
STRUCTURE 14.33 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see MEN1 MEN1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3633 97 842 - 2010 20957198
18 - 3369 - 754 - 2010 20957198
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouthtongue  highly
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine Pygm
ortholog to rattus pygm
Homologene
FAMILY
  • glycogen phosphorylase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing and regulating the breakdown of glycogen to glucose-1-phosphate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • two dimers associate into a tetramer to form the enzymatically active phosphorylase A
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
  • ACTN3 potentially regulates PYGM activity by altering its level of phosphorylation
  • to activate RAC1 and consequently PYGM, PRKCQ phosphorylates ARHGEF6 in T cells
  • cell & other
    REGULATION
    Other allosterically activated by AMP
    allosterically inhibited by ATP, ADP, and glucose-6-phosphate
    ASSOCIATED DISORDERS
    corresponding disease(s) PYGM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS