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FLASH GENE

Symbol

PRKCB

contributors: mct - updated : 07-03-2012

HGNC name	protein kinase C, beta 1
HGNC id	9395

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the myocardium of patients with end-stage heart failure (HF) tumoral     --over   in chronic lymphocytic leukemia, stimulated by VEGFA

Susceptibility

for diabetic nephropathy in type I diabetes mellitus to systemic lupus erythematosus (SLE)

Variant & Polymorphism SNP	rs16972959 increasing the risk of SLE

Candidate gene	for autism
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   PRKCB/ELAVL1 with enhanced VEGFA protein expression is a new potential pharmacological target to counteract pathologies implicating VEGF deregulation, such as diabetic retinopathy

ANIMAL & CELL MODELS