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FLASH GENE
Symbol PRKCB contributors: mct - updated : 07-03-2012
HGNC name protein kinase C, beta 1
HGNC id 9395
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in the myocardium of patients with end-stage heart failure (HF)
tumoral     --over  
in chronic lymphocytic leukemia, stimulated by VEGFA
Susceptibility
  • for diabetic nephropathy in type I diabetes mellitus
  • to systemic lupus erythematosus (SLE)
  • Variant & Polymorphism SNP
  • rs16972959 increasing the risk of SLE
  • Candidate gene for autism
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    PRKCB/ELAVL1 with enhanced VEGFA protein expression is a new potential pharmacological target to counteract pathologies implicating VEGF deregulation, such as diabetic retinopathy
    ANIMAL & CELL MODELS