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FLASH GENE

Symbol

PARP1

contributors: mct/ - updated : 11-12-2019

HGNC name	poly (ADP-ribose) polymerase 1
HGNC id	270

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in NPM-ALK positive anaplastic large cells lymphoma constitutional     --over   early stage of diseased tricuspid valves exhibited higher mRNA levels for PARP1 compared to bicuspid valves

Susceptibility

to breast cancer to Parkinson disease (PD)

Variant & Polymorphism SNP	increasing the risk of breast cancer
	variations in the regulatory region of PARP1 gene might modify the risk for PD

Candidate gene	may participate in the pathophysiology of type I diabetes
	may be site of mutation in Fanconi anemia
Marker
Therapy target
	System Type Disorder Pubmed cancer     synthetic lethal therapeutic strategy for cancer treatment using PARP1 inhibitors cardiovascular atheroma   inhibition of PARP1 may represent a promising therapeutic target in atherosclerosis cancer     link between the PARP1 and G-quadruplex ligands and excellent efficacy of a multi-component strategy based on the use of PARP inhibitors in telomere-based therapy in cancer cancer     co-targeting PARP1 and KLF8 (or other potential PARP1-interacting KLFs) as a novel anti-cancer therapeutic strategy cancer     (PARP1) inhibitors are emerging as an important class of drugs for treating BRCA-deficient cancers cardiovascular valvulopathy   potential therapeutic target in aortic stenosis

ANIMAL & CELL MODELS