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FLASH GENE
Symbol SERPINB2 contributors: mct - updated : 13-11-2024
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
HGNC id 8584
Location 18q22.1      Physical location : 61.554.938 - 61.571.120
Synonym name
  • DNA segment, single copy, probe A24L
  • plasminogen activator inhibitor, type II (arginine-serpin)
    • Synonym symbol(s) PLANH2, PAI, PAI2, PAI-2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 16.19 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   silencer
    text structure
  • a silencer PAUSE-1 in the promoter region, directing an active mechanism of transcriptional repression
  • promoter is controlled by three major transcription regulatory domains: an inducible proximal promoter, an upstream silencer (PAUSE-1), and a distal transactivator region between -5100 and -3300, which appears to overcome inhibition mediated by the silencer
  • promoter contains several AP-1 or AP-1-like consensus sequences, however, their presence does not automatically imply functionality in a given gene promoter
    • MAPPING cloned Y linked N status confirmed
    Map cen - D18S18 - SERPINB4 - [D18S38 - D18S60 - D18S51 /SERPINB2 - D18S68 - SERPINB5 - D18S42 - D18S14 - D18S55 ] - SERPINB3 - TGFBRE - D18S485 - D18S61 - qter
    Authors Schneider (95), LDB, Katz (99)
    Text [deletion in 18QDCR ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2180 - 415 - 2013 2347408
    8 - 1922 43 415 - 2013 2347408
  • secreted SERPINB2 was predominantly in its nonglycosylated 43kDa form
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines tumor cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, trophoblasts
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY serpin family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • delivered to the plasma membrane, apparently together with TGOLN2 in the same vesicles, which after fusion with the membranes released cargo
    • basic FUNCTION
  • serine proteinase inhibitor
  • plasminogen activator inhibitor type 2
  • inhibit extracellular matrix degradation by PLAU (urokinase inhibitor)
  • regulation of Th1 responses appears to be a physiological function of inflammation-associated SERPINB2
  • enzyme inhibitor which is involved in various biological processes including cell differentiation, tissue regrowth and regeneration
  • has a role for promoting the differentiation of epidermal keratinocytes
  • in endothelial cells SERPINB2 induced with inflammatory stimuli, can inhibit proteasome and thus tilt the balance favoring proapoptotic signaling
  • its extracellular concentration significantly increases during inflammation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protecting hematopoietic cells and keratinocytes from inappropriatly timed apoptosis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potent inhibitor of urokinase-type plasminogen activator (PLAU) and also acts as a multifunctional protein
  • physiological interaction between RB1, RBL2 and SERPINB2
  • is a cell survival factor that modulates RB1 repression of proapoptotic signal transduction
  • while SERPINE1 and SERPINB2 function similarly in the control of cellular plasmin generation by PLAT, they may have disparate effects on the alternative functions of PLAT via modulation of its engagement with endocytosis receptors
  • interacts with proteasome and affects its activity in endothelial cells
  • SERPINB2 and TGM2 are downstream mediators in the antiapoptotic response triggered upon TBK1 activation
  • FOSB is the mediator of SERPINB2 transactivator function explaining the orientation dependence observed for SERPINB2 transactivator activity
  • FOSB and JUN can derepress transcription from the SERPINB2 promoter which may have general significance for SERPINB2-expressing cells
  • PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of SERPINB2 and REG1A, and its change in subcellular distribution in response to gastrin is consistent with this role
  • extracellular matrix-associated proteins vitronectin and plasminogen activator inhibitor-2 (SERPINB2) were identified as novel CHL1 interaction partners, promoting CHL1-induced neurite outgrowth and neuronal migration
    • cell & other
    REGULATION
    induced by high levels of expression after stimulation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in oral squamous cell carcinomas
    Susceptibility to myocardial infarction
    Variant & Polymorphism SNP
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS