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FLASH GENE
Symbol YES1 contributors: mct/npt/pgu - updated : 22-05-2019
HGNC name v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
HGNC id 12841
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SH3 and a SH2 domains (signal transduction)
  • a tyrosine kinase domain
    • HOMOLOGY
    interspecies homolog to Yamaguchi sarcoma viral (v-yes-1) oncogene, 1
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
    • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text monopalmitoylated SFK and is biosynthetically transported from the Golgi pool of caveolin to the plasma membrane
    basic FUNCTION
  • monopalmitoylated SFK required for VEGF mitogenic signaling with SRC and FYN, but maintaining distinct properties in the regulation of VEGF-mediated endothelial cell events
  • protein tyrosine kinase related to malignant transformation
  • regulates blood-testis barrier (BTB) and apical ectoplasmic specialization (apical ES) integrity by maintaining proper distribution of integral membrane proteins and actin filament organization at these sites
  • upregulated at the Sertoli cell-cell interface at the blood-testis barrier (BTB) at stages VIII-IX of the seminiferous epithelial cycle of spermatogenesis
  • plays an important role in migration and invasion of epithelial ovarian cancer (EOC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YES1 and LYN play a role in nuclear translocation of EGFR
  • YES1 expression was required in CTNNB1 active cell lines
  • role for YES1 phosphorylation in CTNNB1-driven cancers
  • CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES1 kinase
  • is a proximal glucose-specific activator of cell division cycle control protein 42 (CDC42) in pancreatic islet beta cells
    • cell & other
  • membrane associated
    • REGULATION
    Other its kinase activity is regulated by leukemia inhibitory factor (LIF) and is down-regulated when cells differentiate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    and overexpressed in esophageal squamous cell carcinoma
    tumoral     --other  
    nuclear expression found in cancer cells at the early stages of hepatocarcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • nucleus-located YES1 may be a useful marker to detect early-stage hepatocellular carcinoma
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    is a likely target of male contraceptive research
    ANIMAL & CELL MODELS