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FLASH GENE

Symbol

YES1

contributors: mct/npt/pgu - updated : 22-05-2019

HGNC name	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
HGNC id	12841

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	90.74 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005433 12 - 4685 NP_005424 - 543 - 1998 9794236

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly   mouth tongue     highly Reproductive male system testis     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Reproductive Sertoli cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

Text	highly in embryonic stem (ES) cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a SH3 and a SH2 domains (signal transduction)
	a tyrosine kinase domain

HOMOLOGY

interspecies

homolog to Yamaguchi sarcoma viral (v-yes-1) oncogene, 1

Homologene

FAMILY	protein kinase superfamily
	Tyr protein kinase family
	SRC subfamily

CATEGORY

enzyme , protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
text	monopalmitoylated SFK and is biosynthetically transported from the Golgi pool of caveolin to the plasma membrane

basic FUNCTION	monopalmitoylated SFK required for VEGF mitogenic signaling with SRC and FYN, but maintaining distinct properties in the regulation of VEGF-mediated endothelial cell events
	protein tyrosine kinase related to malignant transformation
	regulates blood-testis barrier (BTB) and apical ectoplasmic specialization (apical ES) integrity by maintaining proper distribution of integral membrane proteins and actin filament organization at these sites
	upregulated at the Sertoli cell-cell interface at the blood-testis barrier (BTB) at stages VIII-IX of the seminiferous epithelial cycle of spermatogenesis
	plays an important role in migration and invasion of epithelial ovarian cancer (EOC)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	YES1 and LYN play a role in nuclear translocation of EGFR
	YES1 expression was required in CTNNB1 active cell lines
	role for YES1 phosphorylation in CTNNB1-driven cancers
	CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES1 kinase
	is a proximal glucose-specific activator of cell division cycle control protein 42 (CDC42) in pancreatic islet beta cells

cell & other

membrane associated

REGULATION

Other

its kinase activity is regulated by leukemia inhibitory factor (LIF) and is down-regulated when cells differentiate

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     and overexpressed in esophageal squamous cell carcinoma tumoral     --other   nuclear expression found in cancer cells at the early stages of hepatocarcinogenesis

Susceptibility

Variant & Polymorphism

Candidate gene	nucleus-located YES1 may be a useful marker to detect early-stage hepatocellular carcinoma
Marker
Therapy target
	System Type Disorder Pubmed reproduction contraception   is a likely target of male contraceptive research

ANIMAL & CELL MODELS