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FLASH GENE
Symbol YES1 contributors: mct/npt/pgu - updated : 22-05-2019
HGNC name v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
HGNC id 12841
Location 18p11.32      Physical location : 721.593 - 812.327
Synonym name
  • viral oncogene yes-1 homolog 1
  • proto-oncogene tyrosine-protein kinase YES
  • cellular yes-1 protein
  • Yamaguchi sarcoma oncogene
    • Synonym symbol(s) Yes, c-yes, HsT441, P61-YES
    EC.number 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 90.74 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4685 - 543 - 1998 9794236
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     mouthtongue  highly
    Reproductivemale systemtestis  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveSertoli cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text highly in embryonic stem (ES) cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SH3 and a SH2 domains (signal transduction)
  • a tyrosine kinase domain
    • HOMOLOGY
    interspecies homolog to Yamaguchi sarcoma viral (v-yes-1) oncogene, 1
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
    • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text monopalmitoylated SFK and is biosynthetically transported from the Golgi pool of caveolin to the plasma membrane
    basic FUNCTION
  • monopalmitoylated SFK required for VEGF mitogenic signaling with SRC and FYN, but maintaining distinct properties in the regulation of VEGF-mediated endothelial cell events
  • protein tyrosine kinase related to malignant transformation
  • regulates blood-testis barrier (BTB) and apical ectoplasmic specialization (apical ES) integrity by maintaining proper distribution of integral membrane proteins and actin filament organization at these sites
  • upregulated at the Sertoli cell-cell interface at the blood-testis barrier (BTB) at stages VIII-IX of the seminiferous epithelial cycle of spermatogenesis
  • plays an important role in migration and invasion of epithelial ovarian cancer (EOC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YES1 and LYN play a role in nuclear translocation of EGFR
  • YES1 expression was required in CTNNB1 active cell lines
  • role for YES1 phosphorylation in CTNNB1-driven cancers
  • CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES1 kinase
  • is a proximal glucose-specific activator of cell division cycle control protein 42 (CDC42) in pancreatic islet beta cells
    • cell & other
  • membrane associated
    • REGULATION
    Other its kinase activity is regulated by leukemia inhibitory factor (LIF) and is down-regulated when cells differentiate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    and overexpressed in esophageal squamous cell carcinoma
    tumoral     --other  
    nuclear expression found in cancer cells at the early stages of hepatocarcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • nucleus-located YES1 may be a useful marker to detect early-stage hepatocellular carcinoma
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    is a likely target of male contraceptive research
    ANIMAL & CELL MODELS