Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TSHB contributors: mct - updated : 17-03-2015
HGNC name thyroid stimulating hormone, beta
HGNC id 12372
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer heteromer , dimer
HOMOLOGY
interspecies ortholog to rattus Tshb
ortholog to murine Tshb
Homologene
FAMILY glycoprotein hormones beta chain family
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
text
  • secreted
    • basic FUNCTION
  • indispensable for the control of thyroid structure and metabolism
  • playing a role as a single molecule switch in the independant control of both bone formation and resorption
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
  • G-protein coupled receptor protein signaling pathway
    • a component
  • heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • forced expressions of NFIB markedly reduced TSHB promoter activity and its mRNA expression
  • Zn-finger region of GATA2 (GATA2-Zf) has an important role in down-regulation of the thyrotropin gene (TSHB) by liganded thyroid hormone receptor (THRB)
  • EYA3 and its partner SIX1 synergistically activate TSHB expression (TSHB plays a key role in the pathway that regulates vertebrate photoperiodism)
  • TRH is a highly specific regulator of TSHB, and TRH mediated induction of TSHB, at least in part by sequential stimulation of the NR4A1-TSHB genes through a PKC and ERK1/2 pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CHNG4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS