Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

TSHB

contributors: mct - updated : 17-03-2015

HGNC name	thyroid stimulating hormone, beta
HGNC id	12372

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       moderately Nervous brain diencephalon hypothalamus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	ortholog to rattus Tshb
	ortholog to murine Tshb

Homologene

FAMILY

glycoprotein hormones beta chain family

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	secreted

basic FUNCTION	indispensable for the control of thyroid structure and metabolism
	playing a role as a single molecule switch in the independant control of both bone formation and resorption

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

G-protein coupled receptor protein signaling pathway

a component

heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin

INTERACTION

DNA

RNA

small molecule

protein	forced expressions of NFIB markedly reduced TSHB promoter activity and its mRNA expression
	Zn-finger region of GATA2 (GATA2-Zf) has an important role in down-regulation of the thyrotropin gene (TSHB) by liganded thyroid hormone receptor (THRB)
	EYA3 and its partner SIX1 synergistically activate TSHB expression (TSHB plays a key role in the pathway that regulates vertebrate photoperiodism)
	TRH is a highly specific regulator of TSHB, and TRH mediated induction of TSHB, at least in part by sequential stimulation of the NR4A1-TSHB genes through a PKC and ERK1/2 pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CHNG4

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS