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FLASH GENE
Symbol TSHB contributors: mct - updated : 17-03-2015
HGNC name thyroid stimulating hormone, beta
HGNC id 12372
Corresponding disease
CHNG4 hypothyroidism, pituitary, familial, nongoitrous
Location 1p13.2      Physical location : 115.572.414 - 115.576.941
Synonym name
  • thyrotropin subunit beta
  • thyrotropin beta chain
    • Synonym symbol(s) TSH-BETA
    DNA
    TYPE functioning gene
    STRUCTURE 4.49 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • MED1 is a ligand-dependent positive cofactor on TSHB pomoter, and is a T3-dependent and -independent coactivator on the TSHB gene promoter
    • MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 537 - 138 - 2012 22752807
    1 splicing 364 - 93 - 2012 22752807
  • hTSHB splice variant
  • dimerises with CGA
  • may participate in the pathogenesis of Hashimoto thyroiditis (HT)
    • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   moderately
    Nervousbraindiencephalonhypothalamus  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Tshb
    ortholog to murine Tshb
    Homologene
    FAMILY glycoprotein hormones beta chain family
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • secreted
    • basic FUNCTION
  • indispensable for the control of thyroid structure and metabolism
  • playing a role as a single molecule switch in the independant control of both bone formation and resorption
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
  • G-protein coupled receptor protein signaling pathway
    • a component
  • heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • forced expressions of NFIB markedly reduced TSHB promoter activity and its mRNA expression
  • Zn-finger region of GATA2 (GATA2-Zf) has an important role in down-regulation of the thyrotropin gene (TSHB) by liganded thyroid hormone receptor (THRB)
  • EYA3 and its partner SIX1 synergistically activate TSHB expression (TSHB plays a key role in the pathway that regulates vertebrate photoperiodism)
  • TRH is a highly specific regulator of TSHB, and TRH mediated induction of TSHB, at least in part by sequential stimulation of the NR4A1-TSHB genes through a PKC and ERK1/2 pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CHNG4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS