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| TGF-beta1 induces amyloid-beta deposition in cerebral blood vessels and meninges of aged transgenic mice overexpressing this cytokine from astrocytes ( | |
overexpression of TGF-beta1 may initiate or promote amyloidogenesis in Alzheimer's disease ( |
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Transgenic mice overexpressing a constitutively active human TGF-beta1 developed fibrosis of the liver, kidney, and adipose tissue, and exhibited a severe reduction in body fat ( |
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transgenic mice that overexpress active TGF-beta1 predominantly in the odontoblasts show a significant reduction in the tooth mineralization, defective dentin formation, and a relatively high branching of dentinal tubules ( |
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Tgfb1(-/-) survival to birth, in addition to dependence on embryonic Tgfbkm2 genotype, also depends on maternal effects ( |
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lack of TGF-beta1 expression in neonatal Tgfb1(-/-) mice results in a widespread increase in degenerating neurons accompanied by reduced expression of synaptophysin and laminin and a prominent microgliosis ( |
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TGF-beta1 deficiency in adult Tgfb1(-/+) mice results in increased neuronal susceptibility to excitotoxic injury ( |
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transgenic mice expressing wild-type TGFbeta1 in the epidermis developed inflammatory skin lesions, with gross appearance of psoriasis-like plaques, generalized scaly erythema, and Koebner's phenomenon ( |
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increased TGF-beta signaling may contribute to the multisystem pathogenesis of mitral valve prolapse, including the development of myxomatous changes of the atrioventricular valves ( |
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Specific inactivation of TGFbeta signaling in neural crest stem cells results in cardiovascular defects and thymic, parathyroid, and craniofacial anomalies ( |
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aortic aneurysm in a mouse model of Marfan syndrome is associated with increased TGF-beta signaling ( |
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male Tgfb1 null mice demonstrate complete inability to mate with females, associated with failure to initiate and/or sustain successful penile intromission or ejaculation |
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mice carrying a Camurati-Engelmann disease-derived mutant TGFB1 show progressive diaphyseal dysplasia ( |