| 1 | TGFB1, TMEFF1
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| High-Dose TGF-β1 Impairs Mesenchymal Stem Cell-Mediated Bone Regeneration via Bmp2 Inhibition.
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| Xu J, Liu J, Gan Y, Dai K, Zhao J, Huang M, Huang Y, Zhuang Y, Zhang X.
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| J. Bone Miner Res. Jan;35(1):167-180. doi: 10.1002/jbmr.3871. Epub 2019 Oct 22. 2020
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| 2 | LMO7, TGFB1
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| LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis.
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| Xie Y, Ostriker AC, Jin Y, Hu H, Sizer AJ, Peng G, Morris AH, Ryu C, Herzog EL, Kyriakides T, Zhao H, Dardik A, Yu J, Hwa J, Martin KA.
|
| Circulation 139(5):679-693. doi: 10.1161/CIRCULATIONAHA.118.034615.
2019
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| 3 | TGFB1, XAF1
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| TGF-β1 protects colon tumor cells from apoptosis through XAF1 suppression.
|
| Moon JR, Oh SJ, Lee CK, Chi SG, Kim HJ.
|
| Int J Oncol 54(6):2117-2126. doi: 10.3892/ijo.2019.4776. Epub 2019 Apr 9.
2019
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| 4 | NRROS, TGFB1
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| LRRC33 is a novel binding and potential regulating protein of TGF-β1 function in human acute myeloid leukemia cells.
|
| Ma W, Qin Y, Chapuy B, Lu C.
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| PLoS One. Oct 10;14(10):e0213482. doi: 10.1371/journal.pone.0213482. eCollection 2019 2019
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| 5 | SMAD2, SMAD4, TGFB1, TGIF1
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| TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling.
|
| Guca E, Suńol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ.
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| Nucleic Acids Res 46(17):9220-9235. doi: 10.1093/nar/gky680.
2018
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| 6 | NODAL, SHH, TGFB1, TGIF1, TGIF2
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| Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.
|
| Wotton D, Taniguchi K.
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| Am J Med Genet C Semin Med Genet 178(2):128-139. doi: 10.1002/ajmg.c.31612. Epub 2018 May 11.
2018
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| 7 | LRRC32, TGFB1
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| Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells.
|
| Liénart S, Merceron R, Vanderaa C, Lambert F, Colau D, Stockis J, van der Woning B, De Haard H, Saunders M, Coulie PG, Savvides SN, Lucas S.
|
| Science Nov 23;362(6417):952-956. doi: 10.1126/science.aau2909. Epub 2018 Oct 25 2018
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| 8 | DACT1, TGFB1
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| TGF-β signaling regulates DACT1 expression in intestinal epithelial cells.
|
| Wang JL, Zhou X, Zhang LF, Li F, Wang BY, Wang WD, Fu W.
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| Biomed Pharmacother. Jan;97:864-869. doi: 10.1016/j.biopha.2017.11.017. Epub 2017 Nov 7. 2018
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| 9 | C1GALT1, C1GALT1C1, TGFB1
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| TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc.
|
| Xiao J, Wang M, Xiong D, Wang Y, Li Q, Zhou J, Chen Q.
|
| Mol Med Rep 15(2):969-974. doi: 10.3892/mmr.2016.6084. Epub 2016 Dec 29.
2017
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| 10 | FHL2, TGFB1
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| LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression.
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| Dahan J, Levillayer F, Xia T, Nouët Y, Werts C, Fanton d'Andon M, Adib-Conquy M, Cassard-Doulcier AM, Khanna V, Chen J, Tordjmann T, Buendia MA, Jouvion G, Wei Y.
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| Mol Cell Biol. May 2;37(10):e00636-16. doi: 10.1128/MCB.00636-16 2017
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| 11 | CD109, TGFB1
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| Soluble CD109 binds TGF-β and antagonizes TGF-β signalling and responses.
|
| Li C, Hancock MA, Sehgal P, Zhou S, Reinhardt DP, Philip A.
|
| Biochem J 473(5):537. doi: 10.1042/BJ20141488. Epub 2015 Nov 30.
2016
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| 12 | PBXIP1, TGFB1
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| HPIP Silencing Prevents Epithelial-Mesenchymal Transition Induced by TGF-β1 in Human Ovarian Cancer Cells
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| Zhang GY, Liu AH, Li GM, Wang JR.
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| Oncol Res. 24(1):33-9. doi: 10.3727/096504016X14575597858654. 2016
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| 13 | CAV1, TGFB1
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| Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes.
|
| He K, Yan X, Li N, Dang S, Xu L, Zhao B, Li Z, Lv Z, Fang X, Zhang Y, Chen YG.
|
| Cell Res 25(6):738-52. doi: 10.1038/cr.2015.60. Epub 2015 May 22.
2015
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| 14 | SLC6A4, STX3, TGFB1
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| Mechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad Pathways.
|
| Nazir S, Kumar A, Chatterjee I, Anbazhagan AN, Gujral T, Priyamvada S, Saksena S, Alrefai WA, Dudeja PK, Gill RK.
|
| PLoS One 10(5):e0120447. doi: 10.1371/journal.pone.0120447. eCollection 2015.
2015
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| 15 | SMAD2, SMAD3, TGFB1
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| Smad2 protects against TGF-β1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis.
|
| Zhang L, Liu C, Meng XM, Huang C, Xu F, Li J.
|
| Mol Cell Biochem 400(1-2):17-28. doi: 10.1007/s11010-014-2258-1. Epub 2014 Oct 29.
2015
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| 16 | IFT88, TGFB1
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| TGF-β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells.
|
| Kawasaki M, Ezura Y, Hayata T, Notomi T, Izu Y, Noda M.
|
| J Cell Physiol 230(11):2788-95. doi: 10.1002/jcp.25005.
2015
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| 17 | PDGFA, TGFB1
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| Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways.
|
| Deng X, Jin K, Li Y, Gu W, Liu M, Zhou L.
|
| Cell Physiol Biochem 36(3):937-46. doi: 10.1159/000430268. Epub 2015 Jun 12.
2015
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| 18 | FYB1, TGFB1
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| The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
|
| Li C, Jiao S, Wang G, Gao Y, Liu C, He X, Zhang C, Xiao J, Li W, Zhang G, Wei B, Chen H, Wang H.
|
| PLoS Pathog 11(4):e1004824. doi: 10.1371/journal.ppat.1004824. eCollection 2015 Apr.
2015
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| 19 | BNC1, TGFB1
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| Basonuclin-1 modulates epithelial plasticity and TGF-β1-induced loss of epithelial cell integrity.
|
| Feuerborn A, Mathow D, Srivastava PK, Gretz N, Gröne HJ.
|
| Oncogene. Feb 26;34(9):1185-95. doi: 10.1038/onc.2014.54. Epub 2014 Mar 24. 2015
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| 20 | TGFB1, TGFB2, TGFB3
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| Role of TGF-β3 in the regulation of immune responses
|
| Okamura T, Morita K, Iwasaki Y, Inoue M, Komai T, Fujio K, Yamamoto K.
|
| Clin Exp Rheumatol. Jul-Aug;33(4 Suppl 92):S63-9. Epub 2015 Oct 12. 2015
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| 21 | ANGPTL2, TGFB1
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| Angiopoietin-like protein 2, a chronic inflammatory mediator, is a new target induced by TGF-β1 through a Smad3-dependent mechanism.
|
| Lee HJ, Kim JH, Kim JH, Martinus RD, Park SH.
|
| Biochem Biophys Res Commun 430(3):981-6. doi: 10.1016/j.bbrc.2012.11.127. Epub 2012 Dec 19. 2013
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| 22 | TGFB1, TP53
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| Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response.
|
| López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM.
|
| Mol Cell 50(4):552-64. doi: 10.1016/j.molcel.2013.04.029.
2013
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| 23 | NOX4, TGFB1
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| Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro.
|
| Chan EC, Peshavariya HM, Liu GS, Jiang F, Lim SY, Dusting GJ.
|
| Biochem Biophys Res Commun 430(3):918-25. doi: 10.1016/j.bbrc.2012.11.138. Epub 2012 Dec 19.
2013
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| 24 | BAG1, TGFB1
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| BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor β (TGF-β1) in colorectal tumour cells.
|
| Skeen VR, Collard TJ, Southern SL, Greenhough A, Hague A, Townsend PA, Paraskeva C, Williams AC.
|
| Oncogene 32(38):4490-9. doi: 10.1038/onc.2012.480. Epub 2012 Oct 29.
2013
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| 25 | NR2F2, SMAD4, TGFB1
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| COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.
|
| Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SY.
|
| Nature 493(7431):236-40. doi: 10.1038/nature11674. Epub 2012 Nov 28.
2013
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| 26 | PRRX1, PRRX2, TGFB1
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| The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling.
|
| Du B, Cawthorn WP, Su A, Doucette CR, Yao Y, Hemati N, Kampert S, McCoin C, Broome DT, Rosen CJ, Yang G, MacDougald OA.
|
| J Biol Chem 288(5):3036-47. doi: 10.1074/jbc.M112.440370. Epub 2012 Dec 17.
2013
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| 27 | SMAD2, TGFB1
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| Calcium-sensing receptor inhibits TGF-β-signaling by decreasing Smad2 phosphorylation.
|
| Organista-Juárez D, Carretero-Ortega J, Vicente-Fermín O, Vázquez-Victorio G, Sosa-Garrocho M, Vázquez-Prado J, Macías-Silva M, Reyes-Cruz G.
|
| IUBMB Life 65(12):1035-42. doi: 10.1002/iub.1232. Epub 2013 Nov 24.
2013
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| 28 | BACH1, MAFK, TGFB1
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| Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.
|
| Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Yamamoto M, Ogami T, Koinuma D, Kato M.
|
| J Biol Chem 288(28):20658-67. doi: 10.1074/jbc.M113.450478. Epub 2013 Jun 4.
2013
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| 29 | FGF9, PITX2, TGFB1
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| Relationship between the localization of fibroblast growth factor 9 in prostate cancer cells and postoperative recurrence.
|
| Teishima J, Shoji K, Hayashi T, Miyamoto K, Ohara S, Matsubara A.
|
| Prostate Cancer Prostatic Dis 15(1):8-14. doi: 10.1038/pcan.2011.48. Epub 2011 Oct 18. 2012
|
| 30 | SIK1, SMURF2, TGFB1
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| Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
|
| Lönn P, Vanlandewijck M, Raja E, Kowanetz M, Watanabe Y, Kowanetz K, Vasilaki E, Heldin CH, Moustakas A.
|
| J Biol Chem 287(16):12867-78. doi: 10.1074/jbc.M111.307249. Epub 2012 Feb 29.
2012
|
| 31 | FGF6, SMAD4, TGFB1
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| A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development.
|
| Han D, Zhao H, Parada C, Hacia JG, Bringas P Jr, Chai Y.
|
| Development 139(9):1640-50. doi: 10.1242/dev.076653. Epub 2012 Mar 21.
2012
|
| 32 | KCNB1, TGFB1
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| TGF-β1 enhances Kv2.1 potassium channel protein expression and promotes maturation of cerebellar granule neurons.
|
| Zhuang JL, Wang CY, Zhou MH, Duan KZ, Mei YA.
|
| J Cell Physiol 227(1):297-307. doi: 10.1002/jcp.22735.
2012
|
| 33 | AXL, TGFB1
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| Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
|
| Bauer T, Zagórska A, Jurkin J, Yasmin N, Köffel R, Richter S, Gesslbauer B, Lemke G, Strobl H.
|
| J Exp Med 209(11):2033-47. doi: 10.1084/jem.20120493. Epub 2012 Oct 15.
2012
|
| 34 | PICK1, TGFB1
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| PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor.
|
| Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG.
|
| Cell Res 22(10):1467-78. doi: 10.1038/cr.2012.92. Epub 2012 Jun 19.
2012
|
| 35 | ERBIN, TGFB1
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| Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway.
|
| Zhou Q, Zeng R, Xu C, Liu L, Chen L, Kou P, Pei G, Bai S, Zhang Y, Li C, Rong S, Han M, Xu G.
|
| J Mol Med (Berl) 90(5):563-74. doi: 10.1007/s00109-011-0833-4.
2012
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| 36 | LRRC32, TGFB1
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| GARP regulates the bioavailability and activation of TGFβ.
|
| Wang R, Zhu J, Dong X, Shi M, Lu C, Springer TA.
|
| Mol Biol Cell. Mar;23(6):1129-39. doi: 10.1091/mbc.E11-12-1018. Epub 2012 Jan 25 2012
|
| 37 | LDS1C, SMAD3, TGFB1
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| Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis.
|
| van de Laar IM, Oldenburg RA, Pals G, Roos-Hesselink JW, de Graaf BM, Verhagen JM, Hoedemaekers YM, Willemsen R, Severijnen LA, Venselaar H, Vriend G, Pattynama PM, Collée M, Majoor-Krakauer D, Poldermans D, Frohn-Mulder IM, Micha D, Timmermans J, Hilhorst-Hofstee Y, Bierma-Zeinstra SM, Willems PJ, Kros JM, Oei EH, Oostra BA, Wessels MW, Bertoli-Avella AM.
|
| Nat Genet 43(2):121-6. Epub 2011 Jan 9.
2011
|
| 38 | DLX4, TGFB1
|
| Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β.
|
| Trinh BQ, Barengo N, Naora H.
|
| Oncogene 30(24):2718-29. doi: 10.1038/onc.2011.4. Epub 2011 Feb 7.
2011
|
| 39 | TGFB1, TGFB3
|
| Latent TGF-β structure and activation.
|
| Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA.
|
| Nature 474(7351):343-9. doi: 10.1038/nature10152.
2011
|
| 40 | FGF2, TGFB1
|
| FGF-2- and TGF-β1-induced downregulation of lumican and keratocan in activated corneal keratocytes by JNK signaling pathway.
|
| Chen J, Wong-Chong J, SundarRaj N.
|
| Invest Ophthalmol Vis Sci. 52(12):8957-64. 2011
|
| 41 | TGFB1
|
| TGFB1 disrupts the angiogenic potential of microvascular endothelial cells of the corpus luteum.
|
| Maroni D, Davis JS.
|
| J Cell Sci 124(Pt 14):2501-10. Epub 2011 Jun 21.
2011
|
| 42 | FSCN1, TGFB1
|
| Fascin protein is critical for transforming growth factor β protein-induced invasion and filopodia formation in spindle-shaped tumor cells.
|
| Sun J, He H, Xiong Y, Lu S, Shen J, Cheng A, Chang WC, Hou MF, Lancaster JM, Kim M, Yang S.
|
| J Biol Chem 286(45):38865-75. doi: 10.1074/jbc.M111.270413. Epub 2011 Sep 13.
2011
|
| 43 | CAV1, CD109, TGFB1
|
| The TGF-β co-receptor, CD109, promotes internalization and degradation of TGF-β receptors.
|
| Bizet AA, Liu K, Tran-Khanh N, Saksena A, Vorstenbosch J, Finnson KW, Buschmann MD, Philip A.
|
| Biochim Biophys Acta 1813(5):742-53. doi: 10.1016/j.bbamcr.2011.01.028. Epub 2011 Feb 2.
2011
|
| 44 | CEACAM3, CEACAM6, CFM1, TGFB1
|
| Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6.
|
| Stanke F, Becker T, Hedtfeld S, Tamm S, Wienker TF, Tümmler B.
|
| Hum Genet 127(4):383-94. Epub 2010 Jan 3.
2010
|
| 45 | TGFB1
|
| Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals.
|
| Karamboulas K, Dranse HJ, Underhill TM.
|
| J Cell Sci 123(Pt 12):2068-76. Epub 2010 May 25.PMID: 20501701 2010
|
| 46 | TGFB1
|
| TGF-beta signaling specifies axons during brain development.
|
| Yi JJ, Barnes AP, Hand R, Polleux F, Ehlers MD.
|
| Cell 142(1):144-57.PMID: 20603020 2010
|
| 47 | MMP14, TGFB1
|
| Stromal regulation of vessel stability by MMP14 and TGFbeta.
|
| Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM.
|
| Dis Model Mech 3(5-6):317-32. Epub 2010 Mar 11.PMID: 20223936 2010
|
| 48 | BMP3, TGFB1
|
| BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway.
|
| Stewart A, Guan H, Yang K.
|
| J Cell Physiol 223(3):658-66.PMID: 20143330 2010
|
| 49 | TGFB1
|
| TGF-beta stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs).
|
| Felthaus O, Ernst W, Driemel O, Reichert TE, Schmalz G, Morsczeck C.
|
| Neurosci Lett 471(3):179-84. Epub 2010 Jan 25.PMID: 20100544 2010
|
| 50 | TGFB1
|
| TGF-â and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance.
|
| Luo S, Kleemann GA, Ashraf JM, Shaw WM, Murphy CT.
|
| Cell 143(2):299-312.
2010
|
| 51 | BMP2, BMP4, GDF11, MSTN, TGFB1, WFIKKN1, WFIKKN2
|
| WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity.
|
| Szláma G, Kondás K, Trexler M, Patthy L.
|
| FEBS J 277(24):5040-50. doi: 10.1111/j.1742-4658.2010.07909.x. Epub 2010 Nov 5.
2010
|
| 52 | TGFB1
|
| Role of transforming growth factor beta in the regulation of thyroid function and growth.
|
| Pisarev MA, Thomasz L, Juvenal GJ.
|
| Thyroid 19(8):881-92. Review.PMID: 19645615 2009
|
| 53 | TGFB1
|
| TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation.
|
| Tang Y, Wu X, Lei W, Pang L, Wan C, Shi Z, Zhao L, Nagy TR, Peng X, Hu J, Feng X, Van Hul W, Wan M, Cao X.
|
| Nat Med 15(7):757-65. Epub 2009 Jul 5.PMID: 19584867 2009
|
| 54 | TGFB1
|
| The essential roles of TGFB1 in reproduction.
|
| Ingman WV, Robertson SA.
|
| Cytokine Growth Factor Rev 20(3):233-9. Epub 2009 Jun 3. Review.PMID: 19497778 2009
|
| 55 | TGFB1, TGFB3
|
| Interactions between TGF-beta1 and TGF-beta3 and their role in medial edge epithelium cell death and palatal fusion in vitro.
|
| Murillo J, Maldonado E, Barrio MC, Del Río A, López Y, Martínez-Sanz E, González I, Martín C, Casado I, Martínez-Alvarez C.
|
| Differentiation 77(2):209-20. Epub 2008 Nov 29.
2009
|
| 56 | TGFB1
|
| Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1.
|
| Hsu LJ, Schultz L, Hong Q, Van Moer K, Heath J, Li MY, Lai FJ, Lin SR, Lee MH, Lo CP, Lin YS, Chen ST, Chang NS.
|
| J Biol Chem. 284(23):16049-59. 2009
|
| 57 | TGFB1
|
| Circulating transforming growth factor-beta in Marfan syndrome.
|
| Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De Backer J, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC; GenTAC Consortium.
|
| Circulation. 120(6):526-32. 2009
|
| 58 | CLCN5, TGFB1
|
| ClC-5 regulates dentin development through TGF-beta1 pathway.
|
| Duan X, Mao Y, Yang T, Wen X, Wang H, Hou J, Xue Y, Zhang R.
|
| Arch Oral Biol 54(12):1118-24. Epub 2009 Oct 29.
2009
|
| 59 | TGFB1
|
| Transforming growth factor-beta enables NFATc1 expression during osteoclastogenesis.
|
| Fox SW, Evans KE, Lovibond AC.
|
| Biochem Biophys Res Commun 366(1):123-8. Epub 2007 Dec 3.
2008
|
| 60 | AKT1, MAPK1, MAPK3, TGFB1, VEGFA, VEGFB, VEGFC
|
| Transforming growth factor-beta1 enhanced vascular endothelial growth factor synthesis in mesenchymal stem cells.
|
| Wang XJ, Dong Z, Zhong XH, Shi RZ, Huang SH, Lou Y, Li QP.
|
| Biochem Biophys Res Commun 365(3):548-54. Epub 2007 Nov 20. Erratum in: Biochem Biophys Res Commun. 2008 Aug 8;372(4):950.
2008
|
| 61 | TGFB1, TGFBR3
|
| Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta.
|
| Hempel N, How T, Cooper SJ, Green TR, Dong M, Copland JA, Wood CG, Blobe GC.
|
| Carcinogenesis 29(5):905-12. Epub 2008 Feb 24.
2008
|
| 62 | TGFB1
|
| Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis.
|
| Bremer LA, Blackman SM, Vanscoy LL, McDougal KE, Bowers A, Naughton KM, Cutler DJ, Cutting GR.
|
| Hum Mol Genet. 17(14):2228-37. 2008
|
| 63 | TGFB1
|
| Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition.
|
| Do TV, Kubba LA, Du H, Sturgis CD, Woodruff TK.
|
| Mol Cancer Res. 6(5):695-705. 2008
|
| 64 | IL1B, IL10, IL6, TGFB1
|
| [Genetic markers of predisposition to an aggressive course of chronic C hepatitis]
|
| Abdullaev SM, Tselishcheva IuI, Samokhodskaia LM, Kvasovka VV, Ignatova TM, Krasnova TN, Bochkov VN, Mukhin NA.
|
| Vestn Ross Akad Med Nauk (1):8-13. Russian. 2007
|
| 65 | CCL2,TGFB1
|
| MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration.
|
| Ma J, Wang Q, Fei T, Han JD, Chen YG.
|
| Blood 109(3):987-94. Epub 2006 Oct 10. 2007
|
| 66 | TGFB1, TGFBR1
|
| ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells.
|
| Safina A, Vandette E, Bakin AV.
|
| Oncogene 26(17):2407-22. Epub 2006 Oct 30.
2007
|
| 67 | DPD1, TGFB1
|
| Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment.
|
| Janssens K, Vanhoenacker F, Bonduelle M, Verbruggen L, Van Maldergem L, Ralston S, Guanabens N, Migone N, Wientroub S, Divizia MT, Bergmann C, Bennett C, Simsek S, Melancon S, Cundy T, Van Hul W.
|
| J Med Genet 43(1):1-11. Epub 2005 May 13. 2006
|
| 68 | TGFB1
|
| Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms.
|
| Shah R, Rahaman B, Hurley CK, Posch PE.
|
| Hum Genet 119(1-2):61-74. Epub 2005 Dec 14. 2006
|
| 69 | TGFB1
|
| The TGFbeta1 gene codon 10 polymorphism contributes to the genetic predisposition to high myopia.
|
| Lin HJ, Wan L, Tsai Y, Tsai YY, Fan SS, Tsai CH, Tsai FJ.
|
| Mol Vis 12:698-703. 2006
|
| 70 | VEGFA, TGFB1
|
| VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis.
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| Ferrari G, Pintucci G, Seghezzi G, Hyman K, Galloway AC, Mignatti P.
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| Proc Natl Acad Sci U S A 103(46):17260-5. Epub 2006 Nov 6. 2006
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| 71 | TGFB1, TGFBR1, RUNX2
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| Repetitive exposure to TGF-beta suppresses TGF-beta type I receptor expression by differentiated osteoblasts.
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| Kim KK, Ji C, Chang W, Wells RG, Gundberg CM, McCarthy TL, Centrella M.
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| Gene 379:175-84. Epub 2006 May 19. 2006
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| 72 | ADAMTS1, TGFB1, IL1B
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| Differential effects of interleukin-1beta and transforming growth factor-beta1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro.
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| Ng YH, Zhu H, Pallen CJ, Leung PC, MacCalman CD.
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| Hum Reprod 21(8):1990-9. Epub 2006 May 4. 2006
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| 73 | CD109, TGFB1, TGFBR1
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| Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes.
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| Finnson KW, Tam BY, Liu K, Marcoux A, Lepage P, Roy S, Bizet AA, Philip A.
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| FASEB J 20(9):1525-7. Epub 2006 Jun 5. 2006
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| 74 | TGFB1
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| Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
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| Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC.
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| Science. 312(5770):117-21. 2006
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| 75 | LMNA, SMAD2, RB, PPP2R3B, TGFB1
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| A-type lamins are essential for TGF-{beta}1 induced PP2A to dephosphorylate transcription factors.
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| Van Berlo JH, Voncken JW, Kubben N, Broers JL, Duisters R, van Leeuwen RE, Crijns HJ, Ramaekers FC, Hutchison CJ, Pinto YM.
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| Hum Mol Genet 14(19):2839-49. Epub 2005 Aug 22. 2005
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| 76 | CF, TGFB1
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| Genetic modifiers of lung disease in cystic fibrosis.
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| Drumm ML, Konstan MW, Schluchter MD, Handler A, Pace R, Zou F, Zariwala M, Fargo D, Xu A, Dunn JM, Darrah RJ, Dorfman R, Sandford AJ, Corey M, Zielenski J, Durie P, Goddard K, Yankaskas JR, Wright FA, Knowles MR; Gene Modifier Study Group.
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| N Engl J Med 353(14):1443-53. 2005
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| 77 | TGFB1, SMAD6, FOXD1
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| Smad6s regulates plasminogen activator inhibitor-1 through a protein kinase C-beta-dependent up-regulation of transforming growth factor-beta.
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| Berg DT, Myers LJ, Richardson MA, Sandusky G, Grinnell BW.
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| J Biol Chem 280(15):14943-7. Epub 2005 Feb 16. 2005
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| 78 | TGFB1
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| Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome.
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| Wurdak H, Ittner LM, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W, Sommer L.
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| Genes Dev. 19(5):530-5. 2005
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| 79 | TGFB1
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| Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder.
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| Li AG, Wang D, Feng XH, Wang XJ.
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| EMBO J. 23(8):1770-81. 2004
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| 80 | TGFB1, DPD1
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| TGFB1 mutations in four new families with Camurati-Engelmann disease: confirmation of independently arising LAP-domain-specific mutations.
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| Kinoshita A, Fukumaki Y, Shirahama S, Miyahara A, Nishimura G, Haga N, Namba A, Ueda H, Hayashi H, Ikegawa S, Seidel J, Niikawa N, Yoshiura K.
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| Am J Med Genet 127A(1):104-7. No abstract available. 2004
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| 81 | TGFB1, VASN
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| Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.
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| Ikeda Y, Imai Y, Kumagai H, Nosaka T, Morikawa Y, Hisaoka T, Manabe I, Maemura K, Nakaoka T, Imamura T, Miyazono K, Komuro I, Nagai R, Kitamura T.
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| Proc Natl Acad Sci U S A 101(29):10732-7. Epub 2004 Jul 09. 2004
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| 82 | COPD2, TGFB1
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| The transforming growth factor-{beta}1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).
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| Celedon JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK.
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| Hum Mol Genet 13(15):1649-1656. Epub 2004 Jun 02. 2004
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| 83 | TGFB1, DPD1
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| Marked phenotypic variability in progressive diaphyseal dysplasia (Camurati-Engelmann disease): report of a four-generation pedigree, identification of a mutation in TGFB1, and review.
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| Wallace SE, Lachman RS, Mekikian PB, Bui KK, Wilcox WR.
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| Am J Med Genet 129A(3):235-47. 2004
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| 84 | TGFB1
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| SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells.
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| Francki A, McClure TD, Brekken RA, Motamed K, Murri C, Wang T, Sage EH.
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| J Cell Biochem. 91(5):915-25. 2004
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| 85 | TGFB1
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| Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells.
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| Zhou S, Eid K, Glowacki J.
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| J Bone Miner Res. 19(3):463-70. 2004
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| 86 | TGFB1
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| TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome.
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| Ng CM, Cheng A, Myers LA, Martinez-Murillo F, Jie C, Bedja D, Gabrielson KL, Hausladen JM, Mecham RP, Judge DP, Dietz HC.
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| J Clin Invest. 114(11):1586-92. 2004
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| 87 | TGFB1
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| Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop.
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| Seidel-Rogol BL, McCulloch V, Shadel GS.
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| Nat Genet 33(1):23-4. 2003
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| 88 | APP, TGFB1
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| A direct interaction between transforming growth factor (TGF)-betas and amyloid-beta protein affects fibrillogenesis in a TGF-beta receptor-independent manner.
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| Mousseau DD, Chapelsky S, De Crescenzo G, Kirkitadze MD, Magoon J, Inoue S, Teplow DB, O'Connor-McCourt MD.
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| J Biol Chem. 278(40):38715-22. 2003
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| 89 | TGFB1
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| APOE and TGF-beta1 genes are associated with obesity phenotypes.
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| Long JR, Liu PY, Liu YJ, Lu Y, Xiong DH, Elze L, Recker RR, Deng HW.
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| J Med Genet. 40(12):918-24. 2003
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| 90 | TGFB1
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| Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice.
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| Tang Y, McKinnon ML, Leong LM, Rusholme SA, Wang S, Akhurst RJ.
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| Hum Mol Genet. 12(13):1579-89. 2003
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| 91 | TGFB1
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| Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain.
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| Brionne TC, Tesseur I, Masliah E, Wyss-Coray T.
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| Neuron. 40(6):1133-45. 2003
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| 92 | SMAD7, TGFB1
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| Deficient Smad7 expression: a putative molecular defect in scleroderma.
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| Dong C, Zhu S, Wang T, Yoon W, Li Z, Alvarez RJ, ten Dijke P, White B, Wigley FM, Goldschmidt-Clermont PJ.
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| Proc Natl Acad Sci U S A 99(6):3908-13. 2002
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| 93 | MED15,NODAL,TGFB1,TGFB2,TGFB3
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| A component of the ARC/Mediator complex required for TGFbeta/Nodal signalling.
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| Kato Y, Habas R, Katsuyama Y, Naar AM, He X.
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| Nature 418(6898):641-6. 2002
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| 94 | TGFB1
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| Polymorphism R25P in the gene encoding transforming growth factor-beta (TGF-beta1) is a newly identified risk factor for proliferative diabetic retinopathy.
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| Beranek M, Kankova K, Benes P, Izakovicova-Holla L, Znojil V, Hajek D, Vlkova E, Vacha J.
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| Am J Med Genet 109(4):278-83. 2002
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| 95 | THBS1, EGF, TGFB1
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| Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization.
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| Okamoto M, Ono M, Uchiumi T, Ueno H, Kohno K, Sugimachi K, Kuwano M.
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| Biochim Biophys Acta 1574(1):24-34. 2002
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| 96 | TGFB2, TGFB1, TGFB3, TGFBR1, TGFBR2, TGFBR3
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| Molecular analysis of TGF-(beta)s and their receptors in human keratinocyte cell lines of different biological behaviour.
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| Bachmeier BE, Ruoss I, Hagedorn HG, Nerlich AG.
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| Int J Mol Med 10(4):371-6. 2002
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| 97 | OMD, TGFB1
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| TGF beta 1 signaling and stimulation of osteoadherin in human odontoblasts in vitro.
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| Lucchini M, Romeas A, Couble ML, Bleicher F, Magloire H, Farges JC.
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| Connect Tissue Res 43(2-3):345-53. 2002
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| 98 | CD44, TGFB1
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| Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.
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| Yu Q, Stamenkovic I.
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| Genes Dev. 14(2):163-76. 2002
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| 99 | TGFB1
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| Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion.
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| Chen Y, Dabovic B, Annes JP, Rifkin DB.
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| FEBS Lett. 517(1-3):277-80. 2002
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| 100 | TGFB1
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| Molecular interactions and functional interference between vitronectin and transforming growth factor-beta.
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| Schoppet M, Chavakis T, Al-Fakhri N, Kanse SM, Preissner KT.
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| Lab Invest. 82(1):37-46 2002
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| 101 | SMAD3, RUNX2, TGFB1
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| TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation.
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| Alliston T, Choy L, Ducy P, Karsenty G, Derynck R.
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| EMBO J 20(9):2254-72. 2001
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| 102 | DPD1, TGFB1
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| Phenotypic variability at the TGF-beta1 locus in Camurati-Engelmann disease.
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| Campos-Xavier B, Saraiva JM, Savarirayan R, Verloes A, Feingold J, Faivre L, Munnich A, Le Merrer M, Cormier-Daire V.
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| Hum Genet 109(6):653-8. 2001
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| 103 | BMP7, TGFB1
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| Transforming growth factor-beta1 supports the rapid morphogenesis of heterotopic endochondral bone initiated by human osteogenic protein-1 via the synergistic upregulation of molecular markers.
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| Matsaba O, Ramoshebi LN, Crooks J, Ripamonti U.
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| Growth Factors 19(2):73-86. 2001
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| 104 | DPD1, TGFB1
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| Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta 1.
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| Saito T, Kinoshita A, Yoshiura Ki, Makita Y, Wakui K, Honke K, Niikawa N, Taniguchi N.
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| J Biol Chem 276(15):11469-72. 2001
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| 105 | RUNX2, TGFB1, TNFRSF11B
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| Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects.
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| Thirunavukkarasu K, Miles RR, Halladay DL, Yang X, Galvin RJ, Chandrasekhar S, Martin TJ, Onyia JE.
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| J Biol Chem 276(39):36241-50. 2001
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| 106 | TGFB1
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| Interaction of TGF-beta1 and rhBMP-2 on human bone marrow stromal cells cultured in collagen gel matrix.
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| Kim MK, Niyibizi C.
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| Yonsei Med J. 42(3):338-44. 2001
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| 107 | TGFB1
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| TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
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| Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA.
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| Nat Cell Biol. 3(8):708-14. 2001
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| 108 | TGFB1
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| TGF-beta signaling in tumor suppression and cancer progression.
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| Derynck R, Akhurst RJ, Balmain A.
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| Nat Genet. 29(2):117-29. 2001
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| 109 | TGFB1
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| TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
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| Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L.
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| Nat Med. 7(5):612-8. 2001
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| 110 | TGFB1
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| Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth.
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| Thyagarajan T, Sreenath T, Cho A, Wright JT, Kulkarni AB.
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| J Biol Chem. 276(14):11016-20. 2001
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| 111 | TGFB1
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| Transforming growth factor beta contributes to progressive diabetic nephropathy.
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| Reeves WB, Andreoli TE.
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| Proc Natl Acad Sci U S A 97(14):7667-9. No abstract available. 2000
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| 112 | DPD1, TGFB1
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| TGF-beta1 stimulates expression of the aromatase (CYP19) gene in human osteoblast-like cells and THP-1 cells.
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| Shozu M, Zhao Y, Simpson ER.
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| Mol Cell Endocrinol 160(1-2):123-33. 2000
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| 113 | DPD1, TGFB1
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| Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.
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| Kinoshita A, Saito T, Tomita Ha, Makita Y, Yoshida K, Ghadami M, Yamada K, Kondo S, Ikegawa S, Nishimura G, Fukushima Y, Nakagomi T, Saito H, Sugimoto T, Kamegaya M, Hisa K, Murray JC, Taniguchi N, Niikawa N, Yoshiura Ki.
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| Nat Genet 26(1):19-20. No abstract available. 2000
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| 114 | ACVRL1, TGFB1
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| Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.
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| Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E.
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| Proc Natl Acad Sci U S A 97(6):2626-31. 2000
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| 115 | DPD1, TGFB1
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| Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease.
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| Janssens K, Gershoni-Baruch R, Guanabens N, Migone N, Ralston S, Bonduelle M, Lissens W, Van Maldergem L, Vanhoenacker F, Verbruggen L, Van Hul W.
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| Nat Genet 26(3):273-5. 2000
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| 116 | TGFB1
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| Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.
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| Saharinen J, Keski-Oja J.
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| Mol Biol Cell. 11(8):2691-704. 2000
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| 117 | TGFB1
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| Genetic control of the circulating concentration of transforming growth factor type beta1.
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| Grainger DJ, Heathcote K, Chiano M, Snieder H, Kemp PR, Metcalfe JC, Carter ND, Spector TD.
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| 118 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
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| Sequence diversity in 36 candidate genes for cardiovascular disorders.
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| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
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| Am J Hum Genet 65(1):183-91. 1999
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| 119 | TGFB1
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| Transforming growth factor-beta stimulates articular chondrocyte cell growth through p44/42 MAP kinase (ERK) activation.
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| Yonekura A, Osaki M, Hirota Y, Tsukazaki T, Miyazaki Y, Matsumoto T, Ohtsuru A, Namba H, Shindo H, Yamashita S.
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| Endocr J 46(4):545-53 1999
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| 120 | DPT, TGFB1
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| Dermatopontin interacts with transforming growth factor beta and enhances its biological activity.
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| Okamoto O, Fujiwara S, Abe M, Sato Y.
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| Biochem J 337 ( Pt 3):537-41. 1999
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| 121 | TGFB1
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| Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta1 and BMP-2.
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| Zhu Y, Oganesian A, Keene DR, Sandell LJ.
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| J Cell Biol. 144(5):1069-80. 1999
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| 122 | TGFB1
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| The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
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| Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D.
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| Cell. 96(3):319-28. 1999
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| 123 | TGFB1
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| Immunohistochemistry and in situ hybridization investigation of transforming growth factor-beta: during odontoblast and ameloblast differentiation.
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| Fan MW, Bian Z, Gao YG.
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| Chin J Dent Res 1(2):17-21 1998
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| 124 | RB1, TGFB1, RBBP9
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| A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.
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| Nat Genet 19(4):371-4. 1998
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| 125 | TGFB1, THBS1
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| Thrombospondin-1 is a major activator of TGF-beta1 in vivo.
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| Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, Boivin GP, Bouck N.
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| Cell. 93(7):1159-70. 1998
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| 126 | TGFB1
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| J Clin Invest. 100(11):2697-713. 1997
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| 127 | TGFB1
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| 128 | DBP, FPR1, IL11, MZF1, NGFG, RTN2, RRAS, SULT2A1, SYT3, TGFB1, ZFP40
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| Detailed comparative map of human chromosome 19q and related regions of the mouse genome.
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| Genomics 35 : 499-508. 1996
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| 129 | TGFB1
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| 130 | TGFB1
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| Science. 271(5252):1120-2. 1996
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| 131 | TGFB1
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| Expression of transforming growth factor-beta 1 in dystrophic patient muscles correlates with fibrosis. Pathogenetic role of a fibrogenic cytokine.
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| 132 | TGFB1
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| Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
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| 133 | TGFB1
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| 134 | TGFB1
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| Mol Biol Cell. 3(2):181-8. 1992
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| 135 | TGFB1
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| Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
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| Cheifetz S, Bellón T, Calés C, Vera S, Bernabeu C, Massagué J, Letarte M.
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| 136 | TGFB1
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| Detection of transforming genes by transfection of DNA from primary soft-tissue tumours.
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| 137 | TGFB1
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| RFLP for the human transforming growth factor beta-1 gene (TGFB) on chromosome 19.
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| 138 | TGFB1
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| T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.
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| 139 | TGFB1
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| Transforming growth factor beta gene maps to human chromosome 19 long arm and to mouse chromosome 7.
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| 140 | TGFB1
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| Transforming growth factor beta gene (TGFB) maps to human chromosome19.
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