| protein
| Endoglin ( |
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Thrombospondin, TSP ( |
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pregnancy zone protein, PZP ( |
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biglycan, decorin and fibromodulin ( |
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betaglycan ( |
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macrophage inflammatory protein-1 alpha, MIP1 ( |
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alpha subunit of p21(RAS) farnesyltransferase (FNTA) ( |
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Dermatopontin ( |
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integrin alpha v beta 6 ( |
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Type IIA procollagen ( |
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activin receptor-like kinase 1, ALK1 ( |
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Latent TGF-beta binding protein-1, LTBP-1 |
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rhBMP-2 ( |
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death-domain associated protein, DAXX ( |
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vitronectin ( |
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Latent TGF-beta binding protein-3, LTBP-3 ( |
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Abeta-(1-40) ( |
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Vasorin ( |
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cell surface hyaluronidase Hyal-2 ( |
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BMP3 |
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TGFB1 signals via IRS2 in kidney epithelial cells |
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WFIKKN1 and WFIKKN2 proteins are antagonists of MSTN and GDF11, but in the case of TGFB1, BMP2 and BMP4 they function as growth factor binding proteins |
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CD109, a GPI-anchored protein, is a TGFB1 co-receptor and a negative regulator of TGFB1 signaling |
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LRRC32 is a latent TGFB1-binding protein that functions in regulating the bioavailability and activation of TGFB1 |
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induces SIK1 levels via a direct transcriptional mechanism that implicates the SMAD proteins) |
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non-neural function of PICK1 is an important negative regulator of TGFB1 signaling |
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CITED2 functions as a molecular switch of TGFA and TGFB1-induced growth control |
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AXL expression is induced by TGFB1 during Langerhans cells (LCs) differentiation and LC precursors acquire AXL early during differentiation |
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BAG1 may regulate TGFB1 expression, a key cytokine in normal colonic tissue homoeostasis |
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BAG1 is a repressor of TGFB1, suggesting a new role for BAG1 in colorectal tumorigenesis |
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NR2F2 interacts with SMAD4 to modulate TGFB1 signalling |
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PRRX1 regulates TGFB1 ligand expression in preadipocytes and thereby modulates adipogenesis |
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induction of ANGPTL2 by TGFB1 was dependent on the SMAD3 protein which binds to the SMAD Binding Element (SBE) region located on the ANGPTL2 promoter) |
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crosstalk between the TGFB1 and TP53 pathways defines a major node of regulation in the cellular stress response, enhancing drug resistance |
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TGFB1 induced expression of transcription factors MAFK and BACH1 |
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SMAD2 and SMAD3 were redundantly essential for TGFB1 signaling to induce histone modifications for IL9 transcription |
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SMAD2 might regulate TGFB1-dependent cellular responses mediated by TGFB1 signaling inhibition |
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expression of BNC1 modulates TGFB1-induced epithelial dedifferentiation of mammary epithelial cells |
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SMAD2 and SMAD3 interact with each other to mediate transforming growth factor-beta (TGFB1)-triggered signaling transduction |
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FYB1 regulates reciprocal TGFB1-integrin crosstalk to protect from Influenza Virus Infection |
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TGFB1 increased the association of SLC6A4 with the soluble STX3 and promoted exocytosis of SLC6A4 |
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CAV1-positive early endosomes may act as a multifunctional device for TGFB1 signaling and TGFB1 receptor recycling and degradation |
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CD109, a glycosylphosphatidylinositol (GPI)-anchored protein, is a novel TGFB1 co-receptor that negatively regulates TGFB1 signalling and responses |
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TGFB1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GALT1 and C1GALT1C1 |
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TGFB1 inhibits WNT signaling to enhance the function of DACT1 inhibiting Wnt signaling |
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TGIF1 and TGIF2 regulate the TGFB1/NODAL signaling pathway and sonic hedgehog (SHH) signaling independently |
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TGIF1 is a multifunctional protein that represses TGFB1-activated transcription by interacting with SMAD2-SMAD4 complexes |
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LMO7 is induced by TGFB1 and serves to limit vascular fibrotic responses through negative feedback regulation of the TGFB1 pathway |
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TGFB1 protects colon tumor cells from apoptosis through XAF1 suppression |
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NRROS is a novel binding and potential regulating protein of TGFB1 function in human acute myeloid leukemia cells |
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| TGF-beta1 induces amyloid-beta deposition in cerebral blood vessels and meninges of aged transgenic mice overexpressing this cytokine from astrocytes ( | |
overexpression of TGF-beta1 may initiate or promote amyloidogenesis in Alzheimer's disease ( |
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Transgenic mice overexpressing a constitutively active human TGF-beta1 developed fibrosis of the liver, kidney, and adipose tissue, and exhibited a severe reduction in body fat ( |
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transgenic mice that overexpress active TGF-beta1 predominantly in the odontoblasts show a significant reduction in the tooth mineralization, defective dentin formation, and a relatively high branching of dentinal tubules ( |
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Tgfb1(-/-) survival to birth, in addition to dependence on embryonic Tgfbkm2 genotype, also depends on maternal effects ( |
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lack of TGF-beta1 expression in neonatal Tgfb1(-/-) mice results in a widespread increase in degenerating neurons accompanied by reduced expression of synaptophysin and laminin and a prominent microgliosis ( |
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TGF-beta1 deficiency in adult Tgfb1(-/+) mice results in increased neuronal susceptibility to excitotoxic injury ( |
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transgenic mice expressing wild-type TGFbeta1 in the epidermis developed inflammatory skin lesions, with gross appearance of psoriasis-like plaques, generalized scaly erythema, and Koebner's phenomenon ( |
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increased TGF-beta signaling may contribute to the multisystem pathogenesis of mitral valve prolapse, including the development of myxomatous changes of the atrioventricular valves ( |
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Specific inactivation of TGFbeta signaling in neural crest stem cells results in cardiovascular defects and thymic, parathyroid, and craniofacial anomalies ( |
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aortic aneurysm in a mouse model of Marfan syndrome is associated with increased TGF-beta signaling ( |
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male Tgfb1 null mice demonstrate complete inability to mate with females, associated with failure to initiate and/or sustain successful penile intromission or ejaculation |
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mice carrying a Camurati-Engelmann disease-derived mutant TGFB1 show progressive diaphyseal dysplasia ( |
