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FLASH GENE

Symbol

LAG3

contributors: mct - updated : 26-03-2024

HGNC name	lymphocyte-activation gene 3
HGNC id	6476

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in chronic lymphocytic leukemia cells, associated with unmutated immunoglobulin variable heavy chain region (IGHV) gene and reduced treatment-free survival (Kotaskova 2010) constitutional         undetectable in preterm neonates while resulting at a level of 176.1±112.6ng/ml in term neonates, and Th-cell polarization could also depend on gestational age

Susceptibility

to multiple sclerosis (MS)

Variant & Polymorphism SNP	at least three significantly associated SNPs--conferred susceptibility to MS (Zhang 2005)

Candidate gene
Marker	testing LAG3 DNA methylation is a predictive biomarker for response to LAG3 immune checkpoint inhibitors in in clear cell renal cell carcinoma
Therapy target
	System Type Disorder Pubmed immunology infectious   LAG3, either alone or in combination with other immune checkpoints, is an ideal target for immunotherapy in COVID19

ANIMAL & CELL MODELS