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FLASH GENE

Symbol

APOA1

contributors: mct/npt - updated : 08-02-2019

HGNC name	apolipoprotein A-I
HGNC id	600

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NNHA , CCLD

Susceptibility

to premature atherosclerosis and to low HDL-cholesterol to premature coronary artery disease

Variant & Polymorphism other	deletion in exon 3 causing a frameshift and heterozygosity for a nucleotide substitution in exon 4 (T>G, L141R) increasing the risk of low HDL-cholesterol
	mutation L178P leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS