motifs/domains
| a large 500 AAs N-terminal membrane domain that mediates transport and consists of 12 transmembrane segments and several membrane-associated segments  |
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TM IX composed of residues 339-363 is critical with pore-lining residues and a kink at the functionally important residue Ser351 |
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a large acidic cytoplasmic C-terminal domain, intracellular regulatory domain, with a C-terminal intracellular tail intrinsically disordered, and SLC9A1 normal function depends on a protein recognition element within this region that may be linked to SLC9A1 trafficking via an acidic ER export motif |
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extracellular regions believed to contribute to cation coordination, transport and sensitivity to inhibitors (extracellular loop 2, EL2, is critical to its function) |
| basic FUNCTION
| regulates intracellular pH by removing one intracellular H+ in exchange for one extracellular Na+ |
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involved in intracellular pH regulation and cell volume |
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involved in regulating ion transport in several organs |
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blood-brain barrier Na/H exchanger, potentially stimulated during ischemia to participate in cerebral edema formation |
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membrane protein that regulates intracellular pH (pHi) by removing one intracellular H(+) in exchange for one extracellular Na(+) |
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with AKT1, has functions, including cell growth and survival, that might be regulated by increased H(+) efflux |
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highly regulated membrane protein that is required for pH homoeostasis in cardiomyocytes |
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responsible for regulating intracellular pH, cell volume, cell migration, and proliferation |
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contributes to the increased DNA synthesis and cell cycle progression of transformed cells by increasing intracellular pH |
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plays pivotal roles in cellular pH and volume homeostasis, and its dysfunction is implicated in several clinically important diseases |
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in mineralizing osteoblasts, slightly basic basal pHi is maintained, and external acid load is dissipated, by high-capacity Na(+) /H(+) exchange via SLC9A1 and SLC9A6 |
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role for SLC9A1 in the long-term regulation of renal tubule function, suggesting that the regulatory interaction whereby SLC9A1 enhances the activity of SLC9A3 in the medullary thick ascending limb and plays a role in the chronic regulation of HCO(3)(-) absorption |
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normally quiescent Na(+)/H(+) exchanger-1 (SLC9A1) defends against proximal tubular epithelial cell (PTC)apoptosis, and is regulated by PI(4,5)P(2) binding |
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regulates intracellular pH by removing a single intracellular H(+) in exchange for one extracellular Na(+) |
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plays an important role in Ca(2+) signaling and cell proliferation in human central nervous system (CNS) pericytes |
