| 1 | SCAR19, SLC9A1
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| Mutation of SLC9A1, encoding the major Na⁺/H⁺ exchanger, causes ataxia-deafness Lichtenstein-Knorr syndrome.
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| Guissart C, Li X, Leheup B, Drouot N, Montaut-Verient B, Raffo E, Jonveaux P, Roux AF, Claustres M, Fliegel L, Koenig M.
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| Hum Mol Genet 24(2):463-70. doi: 10.1093/hmg/ddu461. Epub 2014 Sep 8.
2015
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| 2 | SLC8A1, SLC9A1
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| A crosstalk between Na⁺ channels, Na⁺/K⁺ pump and mitochondrial Na⁺ transporters controls glucose-dependent cytosolic and mitochondrial Na⁺ signals.
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| Nita II, Hershfinkel M, Lewis EC, Sekler I.
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| Cell Calcium 57(2):69-75. doi: 10.1016/j.ceca.2014.12.007.
2015
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| 3 | HSPA13, SLC4A4, SLC9A1
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| Chaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE1.
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| Bae JS, Koo NY, Namkoong E, Davies AJ, Choi SK, Shin Y, Jin M, Hwang SM, Mikoshiba K, Park K.
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| J Biol Chem 288(9):6295-305. doi: 10.1074/jbc.M112.392001. Epub 2013 Jan 9.
2013
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| 4 | SLC9A1
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| Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca²⁺ oscillation in central nervous system pericytes.
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| Nakamura K, Kamouchi M, Arimura K, Nishimura A, Kuroda J, Ishitsuka K, Tokami H, Sugimori H, Ago T, Kitazono T.
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| Arterioscler Thromb Vasc Biol 32(11):2670-7. doi: 10.1161/ATVBAHA.112.254946. Epub 2012 Aug 23.
2012
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| 5 | SLC9A1
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| Structural and functional analysis of extracellular loop 4 of the Nhe1 isoform of the Na(+)/H(+) exchanger.
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| Lee BL, Liu Y, Li X, Sykes BD, Fliegel L.
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| Biochim Biophys Acta 1818(11):2783-90. doi: 10.1016/j.bbamem.2012.06.021. Epub 2012 Jul 6.
2012
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| 6 | EPB41, SLC9A1
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| Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1).
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| Nunomura W, Denker SP, Barber DL, Takakuwa Y, Gascard P.
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| Biochem J 446(3):427-35. doi: 10.1042/BJ20120535.
2012
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| 7 | SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A5, SLC9A6, SLC9A7, SLC9C1
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| Role of the Na(+)/H(+) exchanger on the development of diabetes mellitus and its chronic complications.
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| Sun YM, Su Y, Li J, Tian Y, Wang LF.
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| Biochem Biophys Res Commun 427(2):229-31. doi: 10.1016/j.bbrc.2012.09.050. Epub 2012 Sep 18. Review.
2012
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| 8 | CHP, SLC9A1
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| Dual functional significance of Calcineurin homologous protein 1 (CHP1) binding to Na+/H+ exchanger isoform 1 (NHE1).
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| Matsushita M, Tanaka H, Mitsui K, Kanazawa H.
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| Am J Physiol Cell Physiol m J Physiol Cell Physiol. 2011 May 4. [Epub ahead of print]
2011
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| 9 | BRAF, SLC9A1
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| B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger.
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| Karki P, Li X, Schrama D, Fliegel L.
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| J Biol Chem 286(15):13096-105. Epub 2011 Feb 23.
2011
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| 10 | SLC9A1
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| The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking.
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| Nørholm AB, Hendus-Altenburger R, Bjerre G, Kjaergaard M, Pedersen SF, Kragelund BB.
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| Biochemistry 50(17):3469-80. Epub 2011 Apr 8.
2011
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| 11 | SLC9A1, SLC9A3
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| High sodium intake increases HCO(3)- absorption in medullary thick ascending limb through adaptations in basolateral and apical Na+/H+ exchangers.
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| Good DW, George T, Watts BA 3rd.
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| Am J Physiol Renal Physiol 301(2):F334-43. doi: 10.1152/ajprenal.00106.2011. Epub 2011 May 25.
2011
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| 12 | SLC9A1
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| Structure of human Na+/H+ exchanger NHE1 regulatory region in complex with calmodulin and Ca2+.
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| Köster S, Pavkov-Keller T, Kühlbrandt W, Yildiz Ö.
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| J Biol Chem 286(47):40954-61. doi: 10.1074/jbc.M111.286906. Epub 2011 Sep 19.
2011
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| 13 | SLC9A1, SLC9A6
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| High capacity Na+/H+ exchange activity in mineralizing osteoblasts.
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| Liu L, Schlesinger PH, Slack NM, Friedman PA, Blair HC.
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| J Cell Physiol 226(6):1702-12. doi: 10.1002/jcp.22501.
2011
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| 14 | ARRB1, NEDD4, SLC9A1
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| Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function.
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| Simonin A, Fuster D.
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| J Biol Chem 285(49):38293-303. Epub 2010 Sep 20.
2010
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| 15 | SLC9A1
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| Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling.
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| Lawrence SP, Holman GD, Koumanov F.
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| Biochem J 432(3):515-23. doi: 10.1042/BJ20100717.
2010
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| 16 | SLC9A1, SLC9A2
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| Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin.
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| Lam TI, Wise PM, O'Donnell ME.
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| Am J Physiol Cell Physiol 297(2):C278-89. Epub 2009 May 20.PMID: 19458287 2009
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| 17 | SLC9A1
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| Structural and functional analysis of extracellular loop 2 of the Na(+)/H(+) exchanger.
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| Lee BL, Li X, Liu Y, Sykes BD, Fliegel L.
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| Biochim Biophys Acta 1788(12):2481-8. Epub 2009 Oct 14.PMID: 19835836 2009
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| 18 | AKT1, SLC9A1
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| The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors.
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| Meima ME, Webb BA, Witkowska HE, Barber DL.
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| J Biol Chem 284(39):26666-75. Epub 2009 Jul 21.PMID: 19622752 2009
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| 19 | SLC9A1
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| Structural and functional characterization of transmembrane segment IX of the NHE1 isoform of the Na+/H+ exchanger.
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| Reddy T, Ding J, Li X, Sykes BD, Rainey JK, Fliegel L.
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| J Biol Chem 283(32):22018-30. Epub 2008 May 28.
2008
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| 20 | SLC9A1
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| Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.
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| Nakamura TY, Iwata Y, Arai Y, Komamura K, Wakabayashi S.
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| Circ Res 103(8):891-9. Epub 2008 Sep 5.PMID: 18776042 2008
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| 21 | SLC9A1
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| Oxidative repression of NHE1 gene expression involves iron-mediated caspase activity.
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| Kumar AP, Chang MK, Fliegel L, Pervaiz S, Clement MV.
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| Cell Death Differ 14(10):1733-46. Epub 2007 Jun 15. 2007
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| 22 | SLC9A1
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| Identification and subcellular localization of the Na+/H+ exchanger and a novel related protein in the endocrine pancreas and adrenal medulla.
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| Moulin P, Guiot Y, Jonas JC, Rahier J, Devuyst O, Henquin JC.
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| J Mol Endocrinol 38(3):409-22.
2007
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| 23 | SLC9A1
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| Functional importance of charged residues within the putative intracellular loops in pH regulation by Na+/ H+ exchanger NHE1.
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| Hisamitsu T, Yamada K, Nakamura TY, Wakabayashi S.
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| FEBS J 274(16):4326-35. Epub 2007 Jul 27.
2007
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| 24 | CA2, SLC9A1
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| A novel carbonic anhydrase II binding site regulates NHE1 activity.
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| Li X, Liu Y, Alvarez BV, Casey JR, Fliegel L.
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| Biochemistry 45(7):2414-24.
2006
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| 25 | SLC9A1
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| Cloning and expression of a chloride-dependent Na+-H+ exchanger.
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| Sangan P, Rajendran VM, Geibel JP, Binder HJ.
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| J Biol Chem 277(12):9668-75. Epub 2001 Dec 28. 2002
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| 26 | SLC9A1
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| Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice.
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| Cox GA, Lutz CM, Yang CL, Biemesderfer D, Bronson RT, Fu A, Aronson PS, Noebels JL, Frankel WN.
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| Cell 91(1):139-48. 1997
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| 27 | SLC9A1, SLC9A2, SLC9A3
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| Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA.
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| Dudeja PK, Rao DD, Syed I, Joshi V, Dahdal RY, Gardner C, Risk MC, Schmidt L, Bavishi D, Kim KE, Harig JM, Goldstein JL, Layden TJ, Ramaswamy K.
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| Am J Physiol 271(3 Pt 1):G483-93.PMID: 8843774 1996
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| 28 | SLC9A1, SLC9A2, SLC9A3P, SLC9A3, SLC9A4
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| Chromosomal assignment of four genes encoding Na/H exchanger isoforms inhuman and rat.
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| Szpirer C, et al.
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| Mamm Genome 5 : 153-159. 1994
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| 29 | SLC9A1
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| Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3.
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| Brant SR, et al.
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| Genomics 15 : 668-672. 1993
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| 30 | SLC9A1
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| Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension.
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| Lifton RP, et al.
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| Hypertension 17 : 8-14. 1991
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| 31 | SLC9A1
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| Cloning of the human genomic amiloride-sensitive Na+/H+ antiporter gene, identification of genetic polymorphisms, and localization on the genetic map of chromosome 1p.
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| Lifton RP, et al.
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| Genomics 7 : 131-135. 1990
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| 32 | SLC9A1
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| Polymorphism in the APNH gene, detected by denaturing gradient gel electrophoresis.
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| Dudley CRK, et al.
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| Nucleic Acids Res 18 : 5326. 1990
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| 33 | SLC9A1
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| The Na+/H+ antiporter : a melt polymorphism allows regional mapping to the short arm of chromosome 1.
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| Dudley CRK, et al.
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| Hum Genet 86 : 79-83. 1990
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| 34 | SCAR19, SLC9A1
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| Hearing loss associated with progressive ataxia (Lichtenstein-Knorr disease?). Report of a sporadic case with peculiar neuroradiological findings.
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| Striano S, Barbieri F, Meo R, Bilo L, Cirillo S.
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| Acta Neurol (Napoli) 11(5):351-9.
1989
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| 35 | SLC9A1
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| The human amiloride-sensitive Na+/H+ antiporter : localization to chromosome 1 by in situ hybridization.
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| Mattei MG, et al.
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| Cytogenet Cell Genet 48 : 6-8. 1988
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| 36 | SLC9A1
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| Chromosomal mapping of the amiloride-sensitive Na+/H+ antiporter gene.
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| Mattei MG, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 658. 1987
|