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FLASH GENE
Symbol AK2 contributors: mct - updated : 18-03-2009
HGNC name adenylate kinase 2
HGNC id 362
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Digestiveliver   highly Homo sapiens
Hearing/Equilibriumearinner    Homo sapiens
Lymphoid/Immunespleen     Homo sapiens
Urinarykidney     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet Homo sapiens
Lymphoid/Immunelymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • adenylate kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    basic FUNCTION
  • adenylate kinase 2 implicated in adenine and guanine nucleotide pool homeostasis
  • regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides
  • mitochondrial energy metabolism enzyme, that catalyzes the reversible transfer of a phosphoryl group from ATP to AMP
  • may be playing a role in providing the energy required for the proliferation of hematopoietic precursors and/or in controlling cell apoptosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide
    a component
  • AK2/FADD/caspase-10 (AFAC10) complex, mediating an amplification loop that ensures the execution of the intrinsic apoptosis
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RTDG
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS