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FLASH GENE

Symbol

AK2

contributors: mct - updated : 18-03-2009

HGNC name	adenylate kinase 2
HGNC id	362

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001625 6 - 961 NP_001616 26.5 239 - 2009 19043417 NM_013411 7 - 3606 NP_037543 25.5 232 major form 2009 19043417

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Digestive liver       highly Homo sapiens Hearing/Equilibrium ear inner       Homo sapiens Lymphoid/Immune spleen         Homo sapiens Urinary kidney         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet Homo sapiens Lymphoid/Immune lymphocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

adenylate kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,interspace

basic FUNCTION	adenylate kinase 2 implicated in adenine and guanine nucleotide pool homeostasis
	regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides
	mitochondrial energy metabolism enzyme, that catalyzes the reversible transfer of a phosphoryl group from ATP to AMP
	may be playing a role in providing the energy required for the proliferation of hematopoietic precursors and/or in controlling cell apoptosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

nucleotide

a component

AK2/FADD/caspase-10 (AFAC10) complex, mediating an amplification loop that ensures the execution of the intrinsic apoptosis

INTERACTION

DNA

RNA

small molecule

protein

acting in concert with FADD and caspase-10, AK2 mediates a novel intrinsic apoptotic pathway that may be involved in tumorigenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RTDG

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS