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FLASH GENE

Symbol

AGT

contributors: mct - updated : 19-11-2016

HGNC name	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
HGNC id	333

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

RTD1

Susceptibility

to chronic renal failure in patients with interstitial nephritis (ESRD) to preeclampsia (PE) to pediatric hypertrophic cardiomyopathy with poor outcome to essential hypertension, AGT vascular dementia

Variant & Polymorphism SNP , other	T235M
	associated with progressive septal hypertrophy and left ventricular outflow tract obstruction in children with hypertrophic cardiomyopathy
	T allele or TT homozygote is associated with the onset of ESRD in Caucasians
	AGT M235T polymorphism is associated with PE in Chinese women

Candidate gene
Marker
Therapy target	targeting AGT/AGTR1 signaling could be a novel therapeutic for breast cancer )

ANIMAL & CELL MODELS