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FLASH GENE
Symbol AGT contributors: mct - updated : 19-11-2014
HGNC name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
HGNC id 333
ASSOCIATED DISORDERS
corresponding disease(s) RTD1
Susceptibility
  • to chronic renal failure in patients with interstitial nephritis (ESRD)
  • to preeclampsia (PE)
  • to pediatric hypertrophic cardiomyopathy with poor outcome
  • to essential hypertension, AGT
  • vascular dementia
  • Variant & Polymorphism SNP , other
  • T235M
  • associated with progressive septal hypertrophy and left ventricular outflow tract obstruction in children with hypertrophic cardiomyopathy
  • T allele or TT homozygote is associated with the onset of ESRD in Caucasians
  • AGT M235T polymorphism is associated with PE in Chinese women
  • Candidate gene
    Marker
    Therapy target
  • targeting AGT/AGTR1 signaling could be a novel therapeutic for breast cancer )
  • ANIMAL & CELL MODELS