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FLASH GENE

Symbol

SCG5

contributors: mct/npt - updated : 26-08-2014

HGNC name	secretogranin V (7B2 protein)
HGNC id	10816

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   silenced gene in medulloblastomas (Waha 2007) constitutional     --over   in brain tissues of AD patients, and in the cerebrospinal fluid of amyotrophic lateral sclerosis patients tumoral     --low   silenced by DNA methylation in astrocytic gliomas

Susceptibility

to glucoise intolerance in obesity to colorectal cancer (CRC)

Variant & Polymorphism SNP	SNP -1,701A>G did not associate with risk of T2D but tends to associate with incidence of type 2 diabetes (may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity) (Bouatia-Naji 2007)
	SNPs near SCG5 were strongly associated with increased CRC risk (Jaeger 2008)

Candidate gene	good marker of several neuroendocrine cell dysfunctions (Mbikay 2001)
Marker
Therapy target

ANIMAL & CELL MODELS