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FLASH GENE
Symbol SCG5 contributors: mct/npt - updated : 26-08-2014
HGNC name secretogranin V (7B2 protein)
HGNC id 10816
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
silenced gene in medulloblastomas (Waha 2007)
constitutional     --over  
in brain tissues of AD patients, and in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
tumoral     --low  
silenced by DNA methylation in astrocytic gliomas
Susceptibility
  • to glucoise intolerance in obesity
  • to colorectal cancer (CRC)
  • Variant & Polymorphism SNP
  • SNP -1,701A>G did not associate with risk of T2D but tends to associate with incidence of type 2 diabetes (may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity) (Bouatia-Naji 2007)
  • SNPs near SCG5 were strongly associated with increased CRC risk (Jaeger 2008)
  • Candidate gene good marker of several neuroendocrine cell dysfunctions (Mbikay 2001)
    Marker
    Therapy target
    ANIMAL & CELL MODELS